Evidence map›Paper›PMID 40076337›Full record

ArticleMolecules (Basel, Switzerland)2025

Computational and Experimental Studies on the α-Functionalization of Ketones Using Domino Reactions: A Strategy to Increase Chemoselectivity at the α-Carbon of Ketones.

Hui Sun, Li-Heng Yang, Meng-Yun Fu, Bin Cui

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hui SunManganese Catalysis and Asymmetric Synthesis Laboratory, Hebei University of Science and Technology, Shijiazhuang 050018, China.
Li-Heng YangManganese Catalysis and Asymmetric Synthesis Laboratory, Hebei University of Science and Technology, Shijiazhuang 050018, China.
Meng-Yun FuManganese Catalysis and Asymmetric Synthesis Laboratory, Hebei University of Science and Technology, Shijiazhuang 050018, China.
Bin CuiManganese Catalysis and Asymmetric Synthesis Laboratory, Hebei University of Science and Technology, Shijiazhuang 050018, China.

Funding

National Natural Science Foundation of China 22401072Natural Science Foundation of Hebei Province B2022208024Natural Science Foundation of Hebei Province B2023208015
6 · The paper itself

Abstract

A facile strategy to increase the chemoselectivity of domino reactions was proposed and successfully applied in the α-functionalization of ketones. The strategy involved widening the activation energy of the main reaction and side reaction through intermolecular interactions, thereby increasing the chemoselectivity of the domino reaction. In the proposed α-functionalization reaction, TMSCF

Indexed as

chemoselectivityDFT calculationdomino reactions?-functionalization of carbonyl compounds

Identifiers

PMID40076337
PMCPMC11901711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.