Evidence map›Paper›PMID 40076319›Full record

ReviewMolecules (Basel, Switzerland)2025

A Comprehensive Review of the Phytochemistry, Pharmacology and Other Applications of Euphorbiae Humifusae Herba.

Jian Xiao, Hong Gu, Jiaqing Zhang, Yuqian Xue, Yunyi Chen, Weizhong Zhu, Hong Zhang, Boyi Fan, Wenli Wang

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. 3,3'-Di-O-methylellagic Acid Isolated fromPharmaceuticals (Basel, Switzerland) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jian XiaoSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Hong GuSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Jiaqing ZhangSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Yuqian XueSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Yunyi ChenSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Weizhong ZhuSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Hong ZhangThe Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China.ORCID 0009-0006-0276-2780
Boyi FanSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.
Wenli WangSchool of Pharmacy, Nantong University, 9 Seyuan Road, Nantong 226019, China.

Funding

National College Students Innovation and Entrepreneurship Training Program 202410304061ZNational Natural Science Foundation of China 32100317 and 32370419Zhejiang Province Traditional Chinese Medicine Science and Technology Project 2023ZL455
6 · The paper itself

Abstract

Euphorbiae Humifusae Herba (EHH) is a globally distributed plant commonly utilized in traditional Chinese medicine (TCM) and health food within China. The dried aerial parts of EHH are well-recognized as health foods for the management of diarrhea and other intestinal diseases. Known for its therapeutic effects, such as heat-clearing, detoxification, blood cooling, hemostasis, dampness, elimination, and jaundice relief, EHH has yielded 197 bioactive compounds identified to date, including terpenoids, flavonoids, phenolic acids, tannins, alkaloids, sterols, lactones, coumarins, and other constituents, with flavonoids and terpenoids, highlighting its wide-ranging pharmacological properties and medicinal significance. Despite its popularity in research, limited systematic and comprehensive information has been provided on the EHH. Therefore, we provide an in-depth overview of EHH, covering its botanical characteristics, traditional uses, phytochemical composition, pharmacological properties, and additional applications. Furthermore, it addresses the current challenges and limitations in modern research on EHH, offering critical perspectives to guide future studies in this field.

Indexed as

Drugs, Chinese HerbalPhytochemicalsPlant ExtractsAnimalsHumansMedicine, Chinese TraditionalDrugs, Chinese HerbalPhytochemicalsPlant Extractschemical constituentsEuphorbiae Humifusae Herbapharmacological effectstraditional use

Identifiers

PMID40076319
PMCPMC11901922

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.