ArticleMolecules (Basel, Switzerland)2025
Diverse Structures of Tea Polyphenols from Rougui Wuyi Rock Tea and Their Potential as Inhibitor of 3C-like Protease.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tea polyphenols, the primary bioactive constituents responsible for the various health benefits of tea, can be categorized into different subgroups according to their structural characteristics. However, the distinctions in antiviral activity among the diverse types of polyphenolic compounds remain unexplored. In the present study, fifty-eight tea polyphenols with varied structures, including eleven undescribed compounds, were isolated from Rougui Wuyi rock tea. Their molecular structures were elucidated using comprehensive analytical approaches of NMR, HRMS, CD spectroscopic data and acid hydrolysis. The isolated polyphenol analogs could be structurally classified into two main categories: flavan-3-ols, which include catechins, flavoalkaloids, procyanidins and theasinensins, and flavones, encompassing kaempferol, quercetin, myricetin, and their respective glycosides. The inhibitory activities of fifty-eight tea polyphenols against 3CLpro were assessed in vitro, and eighteen phenolic compounds exhibited inhibitory effects on 3CLpro, with IC
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