Evidence map›Paper›PMID 40076235›Full record

ArticleMolecules (Basel, Switzerland)2025

27-Hydroxymangiferolic Acid Extends Lifespan and Improves Neurodegeneration in

Xiaoyan Gao, Jing Yu, Yin Li, Hang Shi, Lijun Zhang, Minglv Fang, Ying Liu, Cheng Huang, Shengjie Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ethyl Acetate Extract ofCurrent issues in molecular biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoyan GaoSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jing YuSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yin LiSchool of Agriculture and Medicine, Hebei Open University, Shijiazhuang 050080, China.
Hang ShiSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Lijun ZhangSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Minglv FangSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ying LiuSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Cheng HuangSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0003-0704-2943
Shengjie FanSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.ORCID 0000-0002-0184-5641

Funding

Fok Ying Tung Foundation 171036National Natural Science Foundation of China 82073951
6 · The paper itself

Abstract

27-Hydroxymangiferolic acid (27-HMA) is a naturally occurring compound in mango fruits that exhibits diverse biological functions. Here, we show that 27-HMA activates the transcriptional activity of farnesoid X receptor (FXR), a nuclear receptor transcription factor, extending the lifespan and healthspan in

Indexed as

Caenorhabditis elegansLongevityReceptors, Cytoplasmic and NuclearAlzheimer DiseaseAnimalsCaenorhabditis elegans ProteinsDisease Models, AnimalParkinson DiseaseReceptor, Farnesoid X-ActivatedSignal TransductionCaenorhabditis elegans ProteinsReceptor, Farnesoid X-ActivatedReceptors, Cytoplasmic and Nuclear27-hydroxymangiferolic acidAlzheimer’s diseasedetoxificationlifespannuclear receptorParkinson’s disease

Identifiers

PMID40076235
PMCPMC11902184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.