Evidence map›Paper›PMID 40076083›Full record

ArticlePolymers2025

Engineering Hydrogels with Enhanced Adhesive Strength Through Optimization of Poly(Ethylene Glycol) Molecular Weight.

Yin-An Yang, Yu-Feng Ni, Rajan Deepan Chakravarthy, Karl Wu, Mei-Yu Yeh, Hsin-Chieh Lin

Abstract read
In one paragraph

Article in Polymers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yin-An YangDepartment of Chemistry, Chung Yuan Christian University, Taoyuan City 320314, Taiwan.
Yu-Feng NiDepartment of Chemistry, Chung Yuan Christian University, Taoyuan City 320314, Taiwan.
Rajan Deepan ChakravarthyDepartment of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.ORCID 0000-0002-5398-0992
Karl WuDepartment of Orthopaedic Surgery, Far Eastern Memorial Hospital, New Taipei City 220216, Taiwan.ORCID 0000-0003-2193-3451
Mei-Yu YehDepartment of Chemistry, Chung Yuan Christian University, Taoyuan City 320314, Taiwan.ORCID 0000-0003-4825-2891
Hsin-Chieh LinDepartment of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 300093, Taiwan.

Funding

Far Eastern Memorial Hospital National Yang Ming Chiao Tung University Joint Research Pro-gram #FEMH-NYCU 114DN26National Science and Technology Council NSTC 113-2113-M-033-004-, 113-2823-8-A49-001- ,112-2113-M-A49-004-, 111-2923-M-A49-002-MY3
6 · The paper itself

Abstract

Hydrogels are extensively utilized in biomedical fields because of their remarkable properties, including biocompatibility, high water content, flexibility, and elasticity. However, despite substantial progress in hydrogel research, creating a hydrogel adhesive that integrates high stretchability, fatigue resistance, and reversible adhesion continues to pose significant challenges. In this study, we aimed to address these challenges by preparing hydrogels using a combination of acrylic acid, acrylamide, carboxymethylcellulose methacrylate, thiol-functionalized polyhedral oligomeric silsesquioxane, and poly(ethylene glycol) dimethacrylate (PEGDM). By systematically varying the molecular weight of PEG, we were able to precisely adjust the mechanical and adhesive properties of the hydrogels. Our research revealed that a PEG molecular weight of 2000 (resulting in P1 hydrogel) provided a notable adhesive strength of 717.2 kPa on glass surfaces. This performance is particularly impressive given the challenges associated with achieving high adhesive strength while maintaining other desirable hydrogel properties. Beyond its strong adhesive capabilities, the P1 hydrogel also demonstrated exceptional stretchability, support, and fatigue resistance. These characteristics are crucial for applications where the adhesive needs to endure repeated stress and deformation without losing effectiveness. The successful development of P1 hydrogel underscores its potential as a multifunctional adhesive material with a broad range of applications. The ability to tailor the properties of hydrogels through molecular weight adjustments offers a promising approach to creating advanced adhesive solutions that meet the demanding requirements of modern biomedical and industrial applications.

Indexed as

acrylamideadhesivecellulosehydrogelpoly(ethylene glycol)

Identifiers

PMID40076083
PMCPMC11902555

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.