Evidence map›Paper›PMID 40076012›Full record

ArticleAnimals : an open access journal from MDPI2025

Meningeal Lymphatic and Glymphatic Structures in a Pelagic Delphinid (

Olivia N Jackson, Tiffany F Keenan, Nathan P Nelson-Maney, Sentiel A Rommel, William A McLellan, D Ann Pabst, Alexander M Costidis, Kathleen M Caron, Dawn N Kernagis, David S Rotstein and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Olivia N JacksonDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Tiffany F KeenanDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Nathan P Nelson-ManeyDepartment of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sentiel A RommelDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
William A McLellanDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
D Ann PabstDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Alexander M CostidisDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Kathleen M CaronDepartment of Cell Biology and Physiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0002-7033-9232
Dawn N KernagisDEEP, Bristol BS11 8AR, UK.ORCID 0009-0009-2058-8730
David S RotsteinMarine Mammal Pathology Services, Olney, MD 28032, USA.ORCID 0000-0001-7438-2281
Victoria G ThayerCenter for Marine Science and Technologies, North Carolina State University, Morehead City, NC 28557, USA.
Craig A HarmsCenter for Marine Science and Technologies, North Carolina State University, Morehead City, NC 28557, USA.ORCID 0000-0002-1262-9274
Marina A Piscitelli-DoshkovNorth Carolina Aquariums Jennette's Pier, Nags Head, NC 27959, USA.ORCID 0000-0001-7931-0068
Paul DoshkovCape Hatteras National Seashore, Manteo, NC 27954, USA.
Lorian E SchweikertDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.
Kara E YopakDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.ORCID 0000-0002-7870-9066
Molly BraunDepartment of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Michael S TiftDepartment of Biology and Marine Biology, College of Science and Engineering, University of North Carolina Wilmington, Wilmington, NC 28403, USA.

Funding

National Oceanic and Atmospheric Administration Prescott Stranding Grants NA21NMF4390398 & NA22NMF4390241Office of Naval Research Undersea Medicine and Marine Mammal Biology N00014-21-1-2365
6 · The paper itself

Abstract

The glymphatic system, an analog of the peripheral lymphatic system in the brain, and the meningeal lymphatic system are critical to central nervous system health. The glymphatic system functions to distribute cerebrospinal fluid and important compounds throughout the brain and to remove metabolic waste. The flow of cerebrospinal fluid through this system is affected by changes in cerebral blood flow, intracranial pressure, and vascular tone. Cetaceans experience profound cardiorespiratory alterations while diving that can directly affect cerebrospinal fluid and blood flow and, thus, glymphatic function. Our goal was to investigate glymphatic and lymphatic system structures, including perivascular spaces, aquaporin-4 water channels, meningeal lymphatic, and dural venous sinus vessels in the common dolphin (

Indexed as

anatomybraincetaceanCSF mechanicsdiving physiologyglymphatichistochemistrymarine mammalmeningeal lymphaticmorphologyneuropathology

Identifiers

PMID40076012
PMCPMC11899484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.