Evidence map›Paper›PMID 40075729›Full record

ReviewCancers2025

A Thorough Review of the Clinical Applications of Artificial Intelligence in Lung Cancer.

Serafeim-Chrysovalantis Kotoulas, Dionysios Spyratos, Konstantinos Porpodis, Kalliopi Domvri, Afroditi Boutou, Evangelos Kaimakamis, Christina Mouratidou, Ioannis Alevroudis, Vasiliki Dourliou, Kalliopi Tsakiri and 9 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Serafeim-Chrysovalantis KotoulasAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0000-0002-6092-1341
Dionysios SpyratosPulmonary Department, Unit of thoracic Malignancies Research, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, Leoforos Papanikolaou Municipality of Chortiatis, 57010 Thessaloniki, Greece.
Konstantinos PorpodisPulmonary Department, Unit of thoracic Malignancies Research, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, Leoforos Papanikolaou Municipality of Chortiatis, 57010 Thessaloniki, Greece.ORCID 0000-0001-7215-2191
Kalliopi DomvriPulmonary Department, Unit of thoracic Malignancies Research, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, Leoforos Papanikolaou Municipality of Chortiatis, 57010 Thessaloniki, Greece.
Afroditi BoutouPulmonary Department General, Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0000-0001-7366-2038
Evangelos Kaimakamis1st ICU, Medical Informatics Laboratory, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, Leoforos Papanikolaou Municipality of Chortiatis, 57010 Thessaloniki, Greece.ORCID 0000-0003-2081-0337
Christina MouratidouAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0009-0007-8657-2032
Ioannis AlevroudisAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0009-0001-4889-677X
Vasiliki DourliouAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0000-0003-0292-0911
Kalliopi TsakiriAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
Agni SakkouAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
Alexandra MarneriAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
Elena AngeloudiAdult ICU, General Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0000-0003-3492-7915
Ioanna Papagiouvanni4th Internal Medicine Department, General Hospital of Thessaloniki "Ippokrateio", Aristotle's University of Thessaloniki, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0000-0001-5190-0154
Anastasia Michailidou2nd Propaedeutic Internal Medicine Department, General Hospital of Thessaloniki "Ippokrateio", Aristotle's University of Thessaloniki, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
Konstantinos Malandris2nd Internal Medicine Department, General Hospital of Thessaloniki "Ippokrateio", Aristotle's University of Thessaloniki, Konstantinoupoleos 49, 54642 Thessaloniki, Greece.ORCID 0000-0002-5134-2401
Constantinos MourelatosBiology and Genetics Laboratory, Aristotle's University of Thessaloniki, 54624 Thessaloniki, Greece.
Alexandros TsantosPulmonary Department General, Hospital of Thessaloniki "Ippokrateio", Konstantinoupoleos 49, 54642 Thessaloniki, Greece.
Athanasia PatakaRespiratory Failure Clinic and Sleep Laboratory, General Hospital of Thessaloniki "G. Papanikolaou", Aristotle's University of Thessaloniki, Leoforos Papanikolaou Municipality of Chortiatis, 57010 Thessaloniki, Greece.ORCID 0000-0002-3252-6694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

According to data from the World Health Organization (WHO), lung cancer is becoming a global epidemic. It is particularly high in the list of the leading causes of death not only in developed countries, but also worldwide; furthermore, it holds the leading place in terms of cancer-related mortality. Nevertheless, many breakthroughs have been made the last two decades regarding its management, with one of the most prominent being the implementation of artificial intelligence (AI) in various aspects of disease management. We included 473 papers in this thorough review, most of which have been published during the last 5-10 years, in order to describe these breakthroughs. In screening programs, AI is capable of not only detecting suspicious lung nodules in different imaging modalities-such as chest X-rays, computed tomography (CT), and positron emission tomography (PET) scans-but also discriminating between benign and malignant nodules as well, with success rates comparable to or even better than those of experienced radiologists. Furthermore, AI seems to be able to recognize biomarkers that appear in patients who may develop lung cancer, even years before this event. Moreover, it can also assist pathologists and cytologists in recognizing the type of lung tumor, as well as specific histologic or genetic markers that play a key role in treating the disease. Finally, in the treatment field, AI can guide in the development of personalized options for lung cancer patients, possibly improving their prognosis.

Indexed as

artificial intelligenceartificial neural networkconvolutional neural networklung cancerthorough review

Identifiers

PMID40075729
PMCPMC11898928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.