Evidence map›Paper›PMID 40075674›Full record

ReviewCancers2025

Characterizing Cardiotoxicity of FDA-Approved Soft Tissue Sarcoma Targeted Therapies and Immune Checkpoint Inhibitors: A Systematic Review.

Mustafa Houmsse, Andrew Muskara, Damaris Pasca, Arnab Roy, Sana Sughra, Sanam Ghazi, Daniel Addison, Marium Husain

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mustafa HoumsseCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.ORCID 0000-0002-9014-8978
Andrew MuskaraCollege of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Damaris PascaCollege of Graduate Studies, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Arnab RoyCollege of Graduate Studies, Northeast Ohio Medical University, Rootstown, OH 44272, USA.
Sana SughraCardio-Oncology Program, Division of Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Sanam GhaziCardio-Oncology Program, Division of Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Daniel AddisonCardio-Oncology Program, Division of Cardiology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Marium HusainDivision of Medical Oncology, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Funding

SPORE Leukemia Tissue BankP50CA140158 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A · 2009 to 2013
$11.2M
Novel patient biomarkers and mechanisms of TKI associated CardiotoxicityR01HL170038 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Daniel Addison · 2023 to 2026
$2.7M
Therapeutic Strategies to Mitigate Toxicities of Anthracycline-Based TherapeuticsR01HL168045 · NHLBI · OHIO STATE UNIVERSITY · PI Daniel Addison, Sharyn D Baker · 2024 to 2026
$2.2M
Early Detection and Mechanisms of Cancer Immunotherapy Associated CardiotoxicityK23HL155890 · NHLBI · OHIO STATE UNIVERSITY · PI ADDISON, DANIEL · 2021 to 2024
$663k
American Heart Association Robert Wood Johnson Foundation (Harold Amos) grantNCI NIH HHS P50 CA140158NHLBI NIH HHS K23 HL155890NHLBI NIH HHS R01 HL168045NHLBI NIH HHS R01 HL170038NIH HHS K23-HL155890NIH HHS P50-CA140158NIH HHS R01HL168045NIH HHS R01HL170038
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardio-oncologyimmunotherapiesmajor adverse cardiovascular eventssoft tissue sarcomatargeted therapies

Identifiers

PMID40075674
PMCPMC11899116

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.