Evidence map›Paper›PMID 40075671›Full record

ArticleCancers2025

Clinical, Laboratory, and Imaging Features Associated with Arginine Vasopressin Deficiency (Central Diabetes Insipidus) in Erdheim-Chester Disease (ECD).

Sonal Vaid, Juvianee Estrada-Veras, William A Gahl, Nicholas Patronas, Rahul H Dave, Fady Hannah-Shmouni, Kevin O'Brien, Skand Shekhar

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sonal VaidClinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA.
Juvianee Estrada-VerasNational Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
William A GahlNational Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Nicholas PatronasClinical Center, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Rahul H DaveInova Multiple Sclerosis and Neuro-Immunology Center, Fairfax, VA 22031, USA.
Fady Hannah-ShmouniNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0001-6829-6205
Kevin O'BrienNational Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA.ORCID 0000-0002-3056-8516
Skand ShekharClinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA.ORCID 0000-0001-9287-6664

Funding

Observation of Environment and Reproductive-Endocrine EffectsZIAES103402 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHAW, NATALIE · 2024 to 2025
$344k
NIH HHS ZIAES103402
6 · The paper itself

Abstract

purposeErdheim-Chester disease (ECD) is an L Group Langerhans histiocytosis associated with pathogenic variants within the MAPK pathways, most commonly the

methodsA cross-sectional descriptive study of 61 subjects with ECD was conducted at a clinical research center from January 2011 to December 2018, with molecular genetics, baseline biochemical and pituitary endocrine function studies, and dedicated pituitary MRI (or CT) studies. AVP-D and anterior pituitary endocrinopathies (hypothyroidism, hypogonadism, adrenal insufficiency and panhypopituitarism) were assessed. Students'

resultsIn total, 22 out of 61 subjects (36%; 19 males and 3 females) had AVP-D; 18 subjects with AVP-D were in active treatment with desmopressin. Those with versus without AVP-D were younger [mean (±SD): 50.00 (±10.45) vs. 56.72 (±10.45) years], had higher prevalence of

conclusionsAVP-D is common in ECD and accompanied by a higher burden of pituitary endocrinopathies,

Indexed as

arginine vasopressin deficiencyBRAF V600Ecentral diabetes insipidusErdheim–Chester diseasepituitary

Identifiers

PMID40075671
PMCPMC11899333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.