Evidence map›Paper›PMID 40075618›Full record

ArticleCancers2025

Evaluating Therapeutic Efficacy of the Vascular Disrupting Agent OXi8007 Against Kidney Cancer in Mice.

Hashini I Wanniarachchi, Regan Schuetze, Yuling Deng, Khagendra B Hamal, Cyprian I Pavlich, Pouguiniseli E O Tankoano, Caleb Tamminga, Hans Hammers, Payal Kapur, Lorena M A Bueno and 6 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hashini I WanniarachchiDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.ORCID 0000-0003-2050-0910
Regan SchuetzeDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.ORCID 0000-0002-2735-2300
Yuling DengDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.ORCID 0009-0003-3716-3145
Khagendra B HamalDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.
Cyprian I PavlichDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.ORCID 0009-0002-9963-2667
Pouguiniseli E O TankoanoDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.
Caleb TammingaDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.
Hans HammersDepartment of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8837, USA.
Payal KapurDepartment of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9234, USA.
Lorena M A BuenoDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.
Ricardo RayasDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.ORCID 0000-0002-9045-115X
Tianyuan WangDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.ORCID 0000-0002-6976-3626
Li LiuDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.ORCID 0000-0002-9731-6145
Mary Lynn TrawickDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.
Kevin G PinneyDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.ORCID 0000-0003-1262-8631
Ralph P MasonDepartment of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9058, USA.ORCID 0000-0001-7517-3721

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7M
University of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI James Brugarolas · 2016 to 2026
$24.7M
Vascular image-guided optimization of response (VIGOR) to therapy in kidney cancerR01CA244579 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, LI, PINNEY, KEVIN G. · 2020 to 2024
$2.4M
Optoacoustic Tomography System for Small AnimalsS10OD018094 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI MASON, RALPH P. · 2015 to 2015
$510k
Small Animal Bioluminescence and Fluorescence Imaging System (with 3D capability)S10RR024757 · NCRR · UT SOUTHWESTERN MEDICAL CENTER · PI MASON, RALPH P. · 2007 to 2007
$335k
NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA196516NCI NIH HHS R01 CA244579NCRR NIH HHS S10 RR024757NIH HHS 1P30CA142543-14A1NIH HHS 1P50CA196516-19A1NIH HHS 1R01CA244579-20A1NIH HHS S10 OD018094
6 · The paper itself

Abstract

There has been much progress in treating kidney cancer, with several new drugs being approved over the last few years [...].

Indexed as

bioluminescence imagingcabozantinibcheckpoint inhibitorskidney cancerphotoacoustic imagingvascular disrupting agent

Identifiers

PMID40075618
PMCPMC11898701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.