Evidence map›Paper›PMID 40075589›Full record

ArticleCancers2025

Clinical and Pathologic Characteristics of Cytologically Indeterminate Thyroid Nodules with Non-V600E

Ryan Instrum, Christina E Swartzwelder, Ronald A Ghossein, Bin Xu, Babak Givi, Richard J Wong, Brian R Untch, Luc G T Morris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryan InstrumHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-7618-2902
Christina E SwartzwelderHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ronald A GhosseinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Bin XuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0003-4638-9835
Babak GiviHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Richard J WongHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Brian R UntchHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Luc G T MorrisHead and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0002-4417-2280

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundMolecular assays serve as a potential risk stratification tool for cytologically indeterminate thyroid nodules (ITNs).

methodsGenomic profiling data obtained from 1034 pre-operative fine-needle aspiration samples from 955 patients were reviewed. Nodules harboring

resultsThirty-seven patients (3.9%) with non-V600E

conclusionsITNs harboring non-V600E

Indexed as

BRAF mutationclinical outcomesmalignancy riskmolecular testingthyroid cancer

Identifiers

PMID40075589
PMCPMC11899432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.