Evidence map›Paper›PMID 40075537›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2025

Change in diffusion weighted imaging after induction chemotherapy outperforms RECIST guideline for long-term outcome prediction in advanced nasopharyngeal carcinoma.

Qi Yong H Ai, Ho Sang Leung, Frankie K F Mo, Kaijing Mao, Lun M Wong, Yannis Yan Liang, Edwin P Hui, Brigette B Y Ma, Ann D King

Abstract read
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi Yong H AiDepartment of Diagnostic Radiology, The University of Hong Kong, Pokfulam, Hong Kong S.A.R., P.R. China. aqy0621@gmail.com.
Ho Sang LeungDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong S.A.R, P.R. China.
Frankie K F MoDepartment of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong S.A.R, P.R. China.
Kaijing MaoRestorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Lun M WongDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong S.A.R, P.R. China.
Yannis Yan LiangDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong S.A.R, P.R. China.
Edwin P HuiDepartment of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong S.A.R, P.R. China.
Brigette B Y MaDepartment of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir Y.K. Pao Centre for Cancer, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong S.A.R, P.R. China.
Ann D KingDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong S.A.R, P.R. China.

Funding

The Health and Medical Research Fund (HMRF) of The Hong Kong S.A.R. Government 10211386
6 · The paper itself

Abstract

purposeTo investigate change in diffusion weighted imaging (DWI) between pre-treatment (pre-) and after induction chemotherapy (post-IC) for long-term outcome prediction in advanced nasopharyngeal carcinoma (adNPC). MATERIALS AND

methodsMean apparent diffusion coefficients (ADCs) of two DWIs (ADC

resultsUnivariable analysis showed that high ΔADC% predicted good DFS, LRRFS, and DMFS p < 0.05), but did not predict OS (p = 0.40). Neither ADC

conclusionResults suggest that ΔADC% was an independent predictor for long-term outcome and was superior to RECIST guideline for outcome prediction in adNPC. A ΔADC% threshold of ≥ 34.2% may be valuable for selecting patients who respond to treatment for de-escalation of treatment or post-treatment surveillance.

Indexed as

Diffusion Magnetic Resonance ImagingInduction ChemotherapyNasopharyngeal CarcinomaNasopharyngeal NeoplasmsResponse Evaluation Criteria in Solid TumorsAdultAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeDiffusion weighted imagingHead and neck cancerNasopharyngeal carcinomaOutcome predictionRECIST guideline

Identifiers

PMID40075537
PMCPMC11905565

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.