Trial reportItalian journal of pediatrics2025
Comparison of different methods for reducing pain during a heel lance in newborns: a randomized trial.
Trial report in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05797532 (Comparison of Different Methods for Reducing Pain in Heel Blood in Newborns), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Different Methods for Reducing Pain in Heel Blood in Newborns
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of multisensory stimuli on neonatal pain during blood sample collection: a network meta-analysis of randomized controlled trials.European journal of pediatrics · 2025Pooled it
- Effectiveness of Sucrose Versus Breast Milk as Non-Pharmacological Measures in the Management of Neonatal Pain: A Systematic Review.Children (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to compare three different methods [breastfeeding, skin-to-skin contact (SSC), swaddling + holding] to reduce the pain felt by term newborns during a heel lance (HL).
methodsThis was a randomized three-group experimental study. The study sample included 90 newborns, 30 in each group. The data were collected using a pulse oximeter, a voice recorder, an Information Form, the Neonatal Infant Pain Scale (NIPS). The newborns' pain level, heart rate, and oxygen saturation were measured at three different times.
resultsNo difference was found between the groups' mean NIPS scores before the HL procedure (p > 0.05). The mean NIPS scores 10 s after the procedure started and after the HL procedure were the lowest in the breastfeeding group, followed by the SSC and swaddling + holding groups (p < 0.05). There was no difference between the groups' mean heart rates before the procedure; however, there was a significant difference 10 s after the procedure started and after the procedure (p < 0.05).
conclusionBreastfeeding is the most effective method to reduce pain during and after HL procedures in term newborns, followed by SSC and swaddling + holding.
trial registrationThis study was retrospectively registered at ClinicalTrials.gov with the registration number NCT05797532 (date: 04.04.2023).
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