Evidence map›Paper›PMID 40075436›Full record

ArticleVirology journal2025

Epidemiological and etiological investigation of a rare family cluster caused by severe fever with thrombocytopenia syndrome in Anhui Province in 2023.

Na Chu, Wan-Hang Lu, Xiu-Jie Chu, Jia-Bing Wu, Wei Chen, Lei Gong, Dan-Dan Song, Xiao-Wei Tan, Han-Bing Liu, Wen-Wen Liu and 4 more

Abstract read
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Na Chu *Department of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Wan-Hang Lu *Microbiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
Xiu-Jie Chu *Department of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Jia-Bing Wu *Department of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Wei Chen *Hefei Center for Disease Control and Prevention, Hefei, China.
Lei Gong *Department of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Dan-Dan Song *Department of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Xiao-Wei Tan *Feidong Center for Disease Control and Prevention, Hefei, China.
Han-Bing LiuHefei Center for Disease Control and Prevention, Hefei, China.
Wen-Wen LiuHefei Center for Disease Control and Prevention, Hefei, China.
Yong SunMicrobiological Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
Xiu-Zhi ChenDepartment of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Ming LiDepartment of Acute Infectious Disease Prevention and Control, Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China.
Xu-Xiang LiuHefei Center for Disease Control and Prevention, Hefei, China. lxx12342024@163.com.

Funding

Emergency research project of novel coronavirus infection of Anhui province 2022e07020071
6 · The paper itself

Abstract

backgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of the disease has been documented, but the mechanisms of transmission require further investigation.

methodsEpidemiological investigations and genetic analyses of the patients were conducted, and a retrospective cohort study was performed to analyze potential risk factors for person-to-person transmission.

resultsAccording to epidemiologic investigations, 14 secondary cases had a clear history of exposure to blood and body fluids, and 3 secondary cases may have been exposed to aerosols in a poorly ventilated environment. Risk factor assessment revealed that the risk of SFTS was 6.778 times higher [RR = 6.778, 95%CI = 1.570-29.354] among those who had direct blood contact with the indicated patient compared to those who did not, and exposure to bloody secretions from the corpse was associated with a 12.800 times higher risk for SFTS [RR = 12.800, 95%CI = 1.479-110.789] compared to contact with the blood, bloody fluids, or secretions of living patients.

conclusionsContact with the blood of a deceased individual during funeral rites was associated with secondary cases of SFTS. The cluster outbreak is suspected to be due to person-to-person transmission of SFTSV, likely through direct contact with the blood of an SFTS patient, while the spread of aerosols in enclosed environments is also an undeniable mode of transmission.

Indexed as

PhlebovirusSevere Fever with Thrombocytopenia SyndromeAdultAgedChinaFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultDisease clusterEpidemiologic investigationsSevere fever with thrombocytopenia syndrome

Identifiers

PMID40075436
PMCPMC11900035

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.