ArticleBMC ophthalmology2025
The effect of retinopathy of prematurity on visual acuity, refraction, biometric values, retinal and choroidal thickness in school-aged children.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Association of retinopathy of prematurity with early refractive development in mid-preterm infants.Eye (London, England) · 2026Article
- Swept-source optical coherence tomography analysis of retinal and choroidal structures in school-aged children after laser photocoagulation for type 1 retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
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Abstract
backgroundThis study aimed to investigate the long-term effects of retinopathy of prematurity (ROP) on visual function and ocular anatomy. We compared biometric values, foveal thickness, and choroidal thickness among children with a history of ROP (stratified by treatment status), premature infants without ROP, and term-born children.
methodsThis cross-sectional study was conducted between september 2021 and february 2022 at the Ophthalmology Department of Ankara Bilkent City Hospital. The study included 54 eyes from 29 children who received laser photocoagulation treatment for ROP (ROP-Tx Group), 52 eyes from 26 children who developed ROP but did not require treatment (ROP-nonTx Group), 51 eyes from 25 children born prematurely without ROP (Premature Group), and 54 eyes from 27 healthy term children of the same age group (Control Group). One eye of a single premature infant was included in the ROP-nonTx group, while the other eye was included in the Premature group. The first three groups included patients who were followed up under the Retinopathy of Prematurity protocol at Zekai Tahir Burak Hospital between 2008 and 2016, while the control group consisted of 5-12 years old who presented for a routine eye examination without any ocular complaints or history of prematurity. Non-cycloplegic and cycloplegic refractive errors, best corrected visual acuity (BCVA), keratometry, axial length (AL) and anterior chamber depth (ACD), optical coherence tomography (OCT) central macula and choroid thickness measurements were performed in all cases.
resultsPremature infants treated with laser photocoagulation for retinopathy of prematurity exhibited significant differences in all measured ocular parameters compared to the term-born control group (p < 0.05). These parameters included reduced best corrected visual acuity (0.1 logMar), steeper keratometry values (K2: 47.95 Dioptre, K1: 45.83 Dioptre), more myopic spherical equivalent (-0.87 Dioptre), shorter axial length (21.67 mm), decreased anterior chamber depth (3.04 mm), as well as increased central macular thickness (300.50 μm) and decreased central choroidal thickness (268.27 μm). Infants who developed ROP but did not require laser treatment also exhibited significant differences compared to the control group, including steeper keratometry values (K2: 46.62 Dioptre, K1: 45.24 Dioptre) shorter axial length (22.01 mm), and increased central macular thickness (250.05 μm). Interestingly, anterior chamber depth was significantly unexpected way different (3.47 mm) only in the premature group without ROP compared to the term-born controls (p < 0.05).
conclusionsThe study found that prematurity, ROP, and eye development are closely connected. Premature infants who treated with laser photocoagulation for ROP had the most significant differences in eye structure and vision compared to full-term infants. Even premature infants who showed spontaneous regression of ROP still demonstrated differences in ocular anatomy. These results emphasize the importance of closely monitoring premature infants, especially those treated for ROP, to ensure their vision develops properly.
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