ArticleBMC oral health2025
Advanced or delayed? a retrospective study of skeletal maturation in children with a cleft lip and palate.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe developmental patterns of children with cleft lip and palate (CLP) can affect the therapeutic effects. However, a consensus has not been reached on whether the development of children with CLP is delayed or advanced. We aimed to characterize the developmental patterns of children with CLP by skeletal maturation and to explore the relationship between skeletal maturation and dentition in children with CLP.
methodsThis retrospective study included 425 children, aged 4-18 years, categorized into three groups: unilateral cleft lip and palate (UCLP, 157), bilateral cleft lip and palate (BCLP, 134), and non-cleft controls (NCLP, 134). Skeletal maturation stages were assessed using the 5-stage cervical vertebral maturation (CVM) method. Adenoidal and tonsil hypertrophy was also assessed based on cephalometric radiographs. Dentition stages were evaluated based on the eruption of mandibular teeth. Logistic regression models were used to analyze the relationship between CLP and skeletal maturation, adjusting for adenoidal and tonsil hypertrophy and sex. The children were further subgrouped by sex, cleft type, and age to examine developmental patterns and the relationship between skeletal maturation and dentition.
resultsIn both sexes, children with CLP exhibited delayed skeletal maturation at specific developmental stages compared to NCLP children, but eventually caught up to their non-cleft peers. This delay and subsequent catch-up occurred approximately three years earlier in girls with CLP than in boys. While dentition stages showed a strong correlation with CVM stages, the diagnostic utility of dentition for assessing skeletal maturation was found to be limited.
conclusionsChildren with CLP exhibit a delayed onset of the growth spurt, followed by a period of catch-up growth. Additionally, dentition stage should not be used as a surrogate marker for skeletal maturation when evaluating the developmental potential of children with CLP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.