ArticleEye (London, England)2025
Differentiation of anterior chamber pigment and inflammatory cells using swept-source optical coherence tomography: a cross-sectional study.
Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anterior segment optical coherence tomography (AS-OCT) identification of anterior chamber hyper-reflective particles: a meta-analytic approach to methods and metrics.Eye (London, England) · 2026Pooled it
- Functional assessment of the Preserflo MicroShunt implant in pigmentary glaucoma: 2 years follow-up.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Observational
- Novel advances in juvenile idiopathic arthritis associated uveitis.Arthritis research & therapy · 2026Review
- Anterior segment optical coherence tomography in uveitis: A comprehensive review of clinical applications, diagnostic insights, and future directions.Survey of ophthalmologyReview
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND/
objectivesWe aimed to investigate the potential of anterior segment OCT (AS-OCT) in differentiating anterior chamber (AC) pigment and inflammatory cells. SUBJECT/
methodsCross-sectional study of adults with uveitis. The exclusion criterion was corneal opacity sufficient to obscure slit lamp examination of the anterior chamber. Reference testing comprised slit lamp-based detection of pigment and Standardization of Uveitis Nomenclature (SUN) grading of intraocular inflammation. Index testing comprised CASIA2 swept-source AS-OCT acquisition, with semi-automated analysis to detect and measure hyper-reflective particles within the AC. Correlations between AS-OCT-derived counts of different-sized particles and clinical grades were explored using multilevel multivariable regression analyses.
results62 eyes (31 patients) were included. There was a positive correlation between AS-OCT particle counts of >4 pixels (equivalent to >24microns), and SUN grading (adjusted coefficient, adjCoef 24.3, 95% confidence interval 6.3 to 42.3, p = 0.03), strengthened in eyes clinically absent of pigment (adjCoef 20.6, 14.8 to 26.4, p < 0.001). A positive correlation was also noted between particle counts ≤2 pixels and the presence of AC pigment clinically.
conclusionsSwept-source (SS) AS-OCT holds potential utility in differentiating between pigment and cells within the AC, leading to improved management of individuals with or at risk of intraocular inflammation. SS AS-OCT-derived biomarkers may also provide information on uveitis aetiology, supporting the diagnosis of underlying conditions. Further work on a larger cohort, replication by other investigators and clinical teams, and clinical correlation with anterior chamber sampling will enable future clinical validation.
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