ArticleAging clinical and experimental research2025
Correlation between diabetes mellitus and refracture risk in patients with osteoporotic fractures: a retrospective cohort study.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Comparative effects of metformin and lifestyle therapy on bone metabolism markers: A 6-month pilot, open-label randomized-clinical trial.Aging clinical and experimental research · 2026Trial
- Can the Effects of Exercise Therapy on Achilles Tendinopathy Be Enhanced by Adding Nutritional Advice-A Randomized Controlled Pilot Study.Nutrients · 2026Trial
- Evaluation of bone health and fracture risk in type 2 diabetes: a network meta-analysis of anti-diabetic treatments versus placebo.Archives of pharmacal research · 2025Article
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6 authors.
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Abstract
backgroundDiabetes and osteoporosis are frequent long-term conditions. There is little information on the relationship between diabetes and the risk of refracture in people who have osteoporotic fractures (OPFs), even though both conditions have been individually associated with increased fracture risk.
methodsWe conducted a retrospective cohort study using the Osteoporotic Fracture Registry System of the Affiliated Kunshan Hospital of Jiangsu University. The study included 2,255 patients aged 50 years or older who were admitted with OPFs, comprising 107 with diabetes and 2,148 without. The risk of refracture within 1, 3, and 5 years was evaluated using Cox proportional hazard regression models based on whether or not a diabetes diagnosis was made during the admission assessment. Furthermore, the rates of refracture between individuals with and without diabetes were compared using Kaplan-Meier curves.
resultsIn patients with OPFs, diabetes was significantly positively correlated with refracture risk. For the follow-up periods of 1, 3, and 5 years, the hazard ratios (HRs) in the fully adjusted model were 2.83 (95% confidence interval [CI]: 1.09 to 7.39, P-value = 0.033), 2.65 (95% CI: 1.27 to 5.52, P-value = 0.009), and 2.72 (95% CI: 1.39 to 5.32, P-value = 0.004), respectively.
conclusionsThe findings highlight the importance of monitoring bone health and implementing preventative interventions in individuals with diabetes, since they reveal that diabetic patients face a risk of refracture that is more than twice as high as that of non-diabetic individuals.
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