Evidence map›Paper›PMID 40074946›Full record

ReviewAging clinical and experimental research2025

Infectious diseases, cardio-cerebrovascular health and vaccines: pathways to prevention.

Fiona Ecarnot, Jotheeswaran Amuthavalli Thiyagarajan, Mario Barbagallo, Jane Barratt, Tor Biering-Sørensen, Elisabeth Botelho-Nevers, Marco Del Riccio, Marco Goeijenbier, Stefan Gravenstein, Luis Lourenço and 8 more

Abstract readReview
In one paragraph

Review in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Cytomegalovirus and Aging-How Can the Field Move Forward?The Journal of infectious diseases · 2026
    Article
  3. Article
  4. Herpes Zoster in Aging Patients: Risk Factors and Prevention Strategies.International journal of general medicine · 2026
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Fiona EcarnotSINERGIES Unit, University Marie & Louis Pasteur, 19 rue Ambroise Paré, Besançon, 25000, France. Fiona.ecarnot@Univ-fcomte.fr.
Jotheeswaran Amuthavalli ThiyagarajanResponsible officer for Bone Health and Ageing Initiative, Ageing and Health Unit, Department of Maternal, Adolescent Health and Ageing, World Health Organization, Newborn, Child, Geneva, Switzerland.
Mario BarbagalloGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, Via del Vespro 141, Palermo, 90127, Italy.
Jane BarrattInternational Federation on Ageing, Toronto, Canada.
Tor Biering-SørensenCenter for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Elisabeth Botelho-NeversInfectious Diseases Department, University Hospital of Saint-Etienne, Saint-Etienne, 42055 cedex, France.ORCID http://orcid.org/0000-0003-2773-7750
Marco Del RiccioDepartment of Health Sciences, University of Florence, Florence, 50134, Italy.ORCID http://orcid.org/0000-0002-2742-0297
Marco GoeijenbierDepartment of Intensive Care, Spaarne Gasthuis, Haarlem, The Netherlands.
Stefan GravensteinDivision of Geriatrics and Palliative Medicine, Department of Medicine, Alpert Medical School of Brown University, Providence, RI, USA.
Luis LourençoInternational Pharmaceutical Federation (FIP), The Hague, The Netherlands.
Jean-Pierre MichelUniversity of Geneva, Geneva, Switzerland.
Daniela PedicinoFondazione Policlinico Universitario "A.Gemelli"- IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
Cornel SieberInstitute for Biomedicine of Aging, Friedrich-Alexander University, Erlangen-Nürnberg, Germany.
Antoni TorresUniversity of Barcelona, Institut d´Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Ciberes, Barcelona, Spain.
Nicola VeroneseSaint Camillus International University of Health Sciences, Rome, Italy.
Massimo VolpeSIPREC, Italian Society for Cardiovascular Prevention, Rome, Italy.
Thomas WeinkeClinical Practice, Infectious diseases and Gastroenterology, Berlin, Germany.
Stefania MaggiNational Research Council, Neuroscience Institute, Aging Branch, Padova, Italy. stefania.maggi@in.cnr.it.

Funding

World Health Organization 001
6 · The paper itself

Abstract

Cardiovascular and infectious diseases both feature among the leading causes of death among men and women in the world. The pathophysiological pathways of infection and cardiovascular disease intersect, and there is a bidirectional relationship between the two. Vaccines are available for the most common infectious diseases affecting older adults, such as influenza, pertussis, pneumococcal disease, herpes zoster, COVID and respiratory syncytial virus (RSV). In many countries, these vaccines are recommended systematically for older adults and any adults with comorbidities, who are also those most likely to suffer from cardiovascular disease. There is a large body of evidence attesting to the benefits of vaccination on cardio- and cerebrovascular health. The European Interdisciplinary Council for Aging (EICA) and the Italian Society for Cardiovascular Prevention (Società Italiana per la Prevenzione Cardiovascolare, SIPREC) convened a 2-day meeting in June 2024 to review the state of the evidence on the relationship between cardio- and cerebrovascular health and the most common infectious diseases, and the role of vaccines in preventing both infection and its adverse consequences in terms of cardiovascular and cerebrovascular outcomes. We present here the Executive Summary of the proceedings of this meeting.

Indexed as

Cardiovascular DiseasesCerebrovascular DisordersCommunicable DiseasesVaccinesCOVID-19HumansVaccinationVaccinesCardiovascularCerebrovascularCOVIDHerpes zosterInfluenzaPneumococcal diseaseRespiratory syncytial virusSARS-CoV-2Vaccination

Identifiers

PMID40074946
PMCPMC11903628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.