Evidence map›Paper›PMID 40074926›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2025

Dual antiplatelet pre-treatment with aspirin and ticagrelor in ACS patients undergoing unplanned aortocoronary bypass surgery.

Christian Salbach, Mustafa Yildirim, Rebecca Gulba, Barbara Ruth Milles, Moritz Biener, Matthias Mueller-Hennessen, Hauke Hund, Norbert Frey, Evangelos Giannitsis

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christian SalbachDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Mustafa YildirimDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Rebecca GulbaDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Barbara Ruth MillesDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Moritz BienerDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Matthias Mueller-HennessenDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Hauke HundDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Norbert FreyDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Evangelos GiannitsisDepartment of Internal Medicine III, Cardiology, University Hospital of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. evangelos.giannitsis@med.uni-heidelberg.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMajor bleedings following coronary artery bypass grafting (CABG) have significant implications on outcomes in acute coronary syndrome (ACS) patients. Owing fears of fatal bleedings in case of urgent CABG, current guidelines recommend a cessation of P2Y

methodsIn this observational single-center study, ACS patients presenting to an emergency department requiring a CABG were recruited consecutively during a 2-year enrolment period. Baseline characteristics, CABG-related bleedings and all-cause mortality were collected from electronical medical records and related to the timing of CABG and P2Y

resultsA total of 1,502 ACS patients were included, herein 102 (6.8%) underwent urgent CABG. The majority (76.5%) received a routine P2Y

conclusionsNeed of urgent CABG in ACS is infrequent and does not result in an excess of mortality. However, cessation of ticagrelor for at least 48 h before CABG is recommended to minimize rates of CABG-related bleedings.

Indexed as

Acute Coronary SyndromeAspirinCoronary Artery BypassDual Anti-Platelet TherapyPlatelet Aggregation InhibitorsPostoperative HemorrhageTicagrelorAgedCoronary AngiographyFemaleHumansMaleMiddle AgedPurinergic P2Y Receptor AntagonistsTreatment OutcomeAspirinPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsTicagrelorAcute coronary syndromeCoronary artery bypass graftingDual antiplatelet therapyReal-world evidence

Identifiers

PMID40074926
PMCPMC12089244

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.