Evidence map›Paper›PMID 40074908›Full record

ArticleNature2025

Natural behaviour is learned through dopamine-mediated reinforcement.

Jonathan Kasdin, Alison Duffy, Nathan Nadler, Arnav Raha, Adrienne L Fairhall, Kimberly L Stachenfeld, Vikram Gadagkar

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jonathan Kasdin *Department of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Alison Duffy *Department of Neurobiology and Biophysics and Computational Neuroscience Center, University of Washington, Seattle, WA, USA.
Nathan NadlerDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.ORCID 0000-0002-8505-3456
Arnav RahaDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Adrienne L FairhallDepartment of Neurobiology and Biophysics and Computational Neuroscience Center, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6779-953X
Kimberly L StachenfeldDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Vikram GadagkarDepartment of Neuroscience, Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA. vikram.gadagkar@columbia.edu.ORCID 0000-0003-0901-4612

Funding

Neurobiology and Behavior training grantT32MH126036 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber · 2020 to 2026
$2.5M
The Female Songbird as a Novel Mechanistic Model for the Neural Basis of Social EvaluationDP2AT012347 · NCCIH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GADAGKAR, VIKRAM · 2022 to 2025
$2.5M
How is Performance Evaluation Encoded in the Brain?R00NS102520 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GADAGKAR, VIKRAM · 2020 to 2022
$747k
NCCIH NIH HHS DP2 AT012347NIMH NIH HHS T32 MH126036NINDS NIH HHS R00 NS102520
6 · The paper itself

Abstract

Many natural motor skills, such as speaking or locomotion, are acquired through a process of trial-and-error learning over the course of development. It has long been hypothesized, motivated by observations in artificial learning experiments, that dopamine has a crucial role in this process. Dopamine in the basal ganglia is thought to guide reward-based trial-and-error learning by encoding reward prediction errors

Indexed as

DopamineFinchesLearningReinforcement, PsychologyVocalization, AnimalAnimalsBasal GangliaFemaleMaleRewardDopamine

Identifiers

PMID40074908
PMCPMC13252711

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.