ArticleNature2025
MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed.
- Mapping the functional dark proteome in cancer.Nature reviews. Cancer · 2026Review
- Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer.Cancer discovery · 2026Article
- Heterogeneity in cancer: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Molecular cancer · 2026Review
- Research progress on the chemical and pharmacological effects ofInternational journal of molecular medicine · 2026Review
- Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.Nature reviews. Urology · 2026Review
- Restoration of m6A-Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- scAmp enables focal gene amplification analysis from single-cell data.Nature communications · 2026Article
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
- Lethal clinical outcome and immuno-fibrotic contexture in refractory urothelial carcinoma harboring MYC amplification and overexpression.British journal of cancer · 2026Article
- Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.Nature communications · 2026Article
- Plasticity of Non-Apoptotic Residual Tumor Cells After Neoadjuvant Immunochemotherapy: Epigenetic and Microenvironmental Determinants.Biomolecules · 2026Review
- Trimodal, uncertainty-guided whole-slide framework for genome-scale spatial expression and image-only virtual perturbation in cancer cohorts.Genome medicine · 2026Article
- Tumor heterogeneity: development, mechanisms, and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- Beyond chromosomes: exploring the diverse functions of extrachromosomal circular DNA.Journal of advanced research · 2026Review
- Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy.MedComm · 2026Review
- Extrachromosomal DNA Amplification as a Prognostic Factor for Cancer.Journal of personalized medicine · 2026Review
- Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.bioRxiv : the preprint server for biology · 2026Article
- Fra-2 controls the response to the KRAS inhibitor MRTX-1133 in pancreatic ductal adenocarcinoma.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The newfound relationship between extrachromosomal DNAs and excised signal circles.FEBS letters · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors.
Elena Fiorini *Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Antonia Malinova *Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Daniel Schreyer *School of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0002-9788-0168
Davide PasiniDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Michele BevereARC-Net Research Centre, University of Verona, Verona, Italy.ORCID 0000-0001-8778-0860
Giorgia AlessioDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Diego RosaDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Sabrina D'AgostoARC-Net Research Centre, University of Verona, Verona, Italy.
Luca AzzolinComputational Biology Research Centre, Human Technopole, Milan, Italy.
Salvatore MiliteComputational Biology Research Centre, Human Technopole, Milan, Italy.
Silvia AndreaniARC-Net Research Centre, University of Verona, Verona, Italy.ORCID 0000-0002-3715-1553
Francesca LupoDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Lisa VeghiniDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.
Sonia GrimaldiARC-Net Research Centre, University of Verona, Verona, Italy.ORCID 0000-0002-3675-3560
Serena PedronDepartment of Diagnostics and Public Health, University of Verona, Verona, Italy.
Monica CastellucciCentro Piattaforme Tecnologiche, University of Verona, Verona, Italy.
Craig NourseCancer Research UK Beatson Institute, Glasgow, UK.
Roberto SalviaDepartment of General and Pancreatic Surgery, The Pancreas Institute, University of Verona, Verona, Italy.
Giuseppe MalleoDepartment of General and Pancreatic Surgery, The Pancreas Institute, University of Verona, Verona, Italy.
Andrea RuzzenenteDepartment of Surgical Sciences, Division of General and Hepatobiliary Surgery, University of Verona, Verona, Italy.
Alfredo GuglielmiDepartment of Surgical Sciences, Division of General and Hepatobiliary Surgery, University of Verona, Verona, Italy.
Michele MilellaSection of Medical Oncology, Department of Medicine, University of Verona, Verona, Italy.
Rita T LawlorDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID 0000-0003-3160-0634
Claudio LuchiniDepartment of Diagnostics and Public Health, University of Verona, Verona, Italy.ORCID 0000-0003-4901-4908
Antonio AgostiniDepartment of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Carmine CarboneDepartment of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Christian PilarskyDepartment of Surgery, Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0002-7968-3283
Andrea SottorivaComputational Biology Research Centre, Human Technopole, Milan, Italy.ORCID 0000-0001-6709-9533
Aldo ScarpaARC-Net Research Centre, University of Verona, Verona, Italy.ORCID 0000-0003-1678-739X
David A TuvesonCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Peter BaileySchool of Cancer Sciences, University of Glasgow, Glasgow, UK. peter.bailey@research.fchampalimaud.org.
Vincenzo CorboDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy. vincenzo.corbo@univr.it.ORCID 0000-0002-6340-8009
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intratumour heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance
Indexed as
Carcinoma, Pancreatic DuctalCell PlasticityGenes, mycGenetic HeterogeneityPancreatic NeoplasmsProto-Oncogene Proteins c-mycAnimalsCell Line, TumorDNA Copy Number VariationsFemaleGene AmplificationGene DosageHumansMiceTumor MicroenvironmentMYC protein, humanProto-Oncogene Proteins c-myc
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.