ArticleNature2025
TGFβ links EBV to multisystem inflammatory syndrome in children.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines on the Use of Therapeutic Apheresis in Clinical Practice-Evidence-Based Approach From the Writing Committee of the American Society for Apheresis: The Tenth Special Issue.Journal of clinical apheresis · 2026Guideline
- Current Prognostic Models Fail to Reliably Distinguish Kawasaki Disease From Pediatric Multisystem Inflammatory Syndrome Temporally Associated With COVID-19.The Pediatric infectious disease journal · 2026Article
- Virus reactivation in acute and long COVID-19.Nature · 2026Article
- Diagnostic approaches to Kawasaki disease worldwide: the results from the JIR-CliPS network.Rheumatology (Oxford, England) · 2026Article
- The HIF-1α-Th17/Treg axis in pediatric infectious mononucleosis: a clinical investigation of metabolic-immune dysregulation.BMC infectious diseases · 2026Article
- Immune-metabolic trajectories delineate subgroups in paediatric long COVID.Nature communications · 2026Article
- Shared TCR Vβ21.3+ T cell immunological signature between MIS-A and MIS-C.Journal of human immunity · 2026Article
- EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis.bioRxiv : the preprint server for biology · 2026Article
- Epstein-Barr Virus Infection at Single-Cell Resolution.Journal of medical virology · 2026Review
- Assessing Seroprevalence and Infection Dynamics of Oncogenic Gammaherpesviruses in South African Paediatric Patients Presenting with Inflammatory Conditions.International journal of molecular sciences · 2026Article
- MAGL-18c attenuates LPS-induced sepsis-associated liver injury by inhibiting TGF-β/Smad signaling and remodeling medium- and long-chain fatty acid metabolism.Frontiers in immunology · 2026Article
- Epstein Barr virus antigen-induced autoantibodies against complement C1q exacerbate renal disease in lupus-prone mice.Frontiers in immunology · 2026Article
- Viral Coinfections Potentially Associated with Feline Chronic Gingivostomatitis in Cats with Feline Infectious Peritonitis.Viruses · 2025Article
- The seven enigmas of SARS-CoV-2: from the past to the future.Journal of human immunity · 2025Article
- Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases.Disease models & mechanisms · 2025Article
- Article
- Interferons in health and disease.Cell · 2025Review
- Vaxtherapy, a Multiphase Therapeutic Protocol Approach for Longvax, the COVID-19 Vaccine-Induced Disease: Spike Persistence as the Core Culprit and Its Downstream Effects.Diseases (Basel, Switzerland) · 2025Article
- Review
- A role for TGFβ and EBV in MIS-C pathogenesis.Nature reviews. Rheumatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors.
Carl Christoph GoetzkeGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany. carl-christoph.goetzke@charite.de.ORCID 0000-0003-3407-7631
Mona MassoudGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Stefan FrischbutterInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3971-7343
Gabriela Maria GuerraGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Marta Ferreira-GomesGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.ORCID 0000-0002-7171-7952
Frederik HeinrichGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.ORCID 0000-0001-6097-5422
Anne Sae Lim von StuckradDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sebastian WisniewskiDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-9129-8997
Jan Robin LichaGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Marina BondarevaGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Lisa EhlersGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.ORCID 0000-0001-8737-001X
Samira Khaldi-PlassartNational Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE), Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.ORCID 0009-0003-1485-2634
Etienne JavouheyPediatric Intensive Care Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.
Sylvie PonsJoint Research Unit, Hospices Civils de Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.ORCID 0000-0002-6286-0546
Sophie Trouillet-AssantJoint Research Unit, Hospices Civils de Lyon-bioMérieux, Hospices Civils de Lyon, Lyon Sud Hospital, Pierre-Bénite, France.
Yasemin OzsurekciDepartment of Pediatric Infectious Diseases, Hacettepe University, Ankara, Turkey.ORCID 0000-0001-8662-6909
Yu ZhangLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Maria Cecilia PoliFaculty of Medicine, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.ORCID 0000-0001-6817-0573
Valentina DiscepoloDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.
Andrea Lo VecchioDepartment of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.ORCID 0000-0003-4181-6842
Bengü SahinDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Murielle VerboomHannover Medical School, Institute of Transfusion Medicine and Transplant Engineering, Hannover, Germany.ORCID 0000-0001-8260-2045
Michael HallenslebenHannover Medical School, Institute of Transfusion Medicine and Transplant Engineering, Hannover, Germany.ORCID 0000-0002-7555-218X
Anja Isabelle HeuhsenGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Camila AstudilloImmunology and Rheumatology Unit, Hospital de Niños Dr. Roberto del Río, Santiago, Chile.
Yazmin EspinosaImmunology and Rheumatology Unit, Hospital de Niños Dr. Roberto del Río, Santiago, Chile.ORCID 0000-0003-0980-1376
Maria Cecilia Vial CoxFaculty of Medicine, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
Kerry DobbsLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3432-3137
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Gina A Montealegre SanchezLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Mary MaglioccoLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Karyl BarronLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Jeffrey DanielsonLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Lev PetrovTranslational Immunology, Berlin Institute of Health (BIH) and Charité University Medicine, Berlin, Germany.
Nadine UnterwalderDepartment of Microbiology and Hygiene, Labor Berlin, Charité-Vivantes, Berlin, Germany.
Birgit SawitzkiTranslational Immunology, Berlin Institute of Health (BIH) and Charité University Medicine, Berlin, Germany.ORCID 0000-0001-8166-8579
Mareen MatzBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Katrin LehmannGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Alexander GratoppDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Horst von BernuthDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-5812-7675
Lisa-Marie BurkhardtBerlin Center for Advanced Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-9598-2304
Niklas WieseBerlin Center for Advanced Therapies, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Lena PeterBerlin Institute of Health (BIH)-Center for Regenerative Therapies (B-CRT), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-1205-7445
Michael Schmueck-HenneresseBerlin Institute of Health (BIH)-Center for Regenerative Therapies (B-CRT), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-5964-9179
Leila AminiBerlin Institute of Health (BIH)-Center for Regenerative Therapies (B-CRT), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-4855-5905
Marcus MaurerInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-4121-481X
Jobst Fridolin RoehmelDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-1535-8852
Benjamin E GewurzDivision of Infectious Disease, Brigham and Women's Hospital and Program in Virology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3965-3418
Lael M YonkerMucosal Immunology and Biology Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-1711-8227
Mario WitkowskiGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.ORCID 0000-0002-8791-5558
Andrey KruglovGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.
Marcus Alexander MallDepartment of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-4057-2199
Helen C SuLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-5582-9110
Seza OzenDepartment of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey.ORCID 0000-0003-2883-7868
Andreas RadbruchGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.ORCID 0000-0001-5753-0000
Alexandre BelotNational Reference Center for Rheumatic, Autoimmune and Systemic Diseases in Children (RAISE), Pediatric Nephrology, Rheumatology, Dermatology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Lyon, France.ORCID 0000-0003-4902-5332
Pawel DurekGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany.ORCID 0000-0002-6179-0670
Tilmann KallinichGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany. tilmann.kallinich@charite.de.ORCID 0000-0003-2404-9397
Mir-Farzin MashreghiGerman Rheumatology Research Center, a Leibniz-Institute (DRFZ), Berlin, Germany. mashreghi@drfz.de.ORCID 0000-0002-8015-6907
Funding
Regulation of the Epstein-Barr Virus Lytic SwitchR01AI164709 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Benjamin Elison Gewurz · 2021 to 2026
$3.1MDefining neutrophil pathobiology in pediatric Long COVIDR01HL173059 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Lael Yonker · 2024 to 2026
$2.4MEpstein-Barr Virus Driven Tonsillar Versus Peripheral B-cell One-Carbon Metabolic Network RemodelingR01DE033907 · NIDCR · BRIGHAM AND WOMEN'S HOSPITAL · PI Benjamin Elison Gewurz · 2024 to 2026
$1.5MNHLBI NIH HHS R01 HL173059NIAID NIH HHS R01 AI164709NIDCR NIH HHS R01 DE033907
Abstract
In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock
Indexed as
COVID-19Epstein-Barr Virus InfectionsHerpesvirus 4, HumanSystemic Inflammatory Response SyndromeTransforming Growth Factor betaAdolescentB-LymphocytesChildChild, PreschoolFemaleHumansImmunologic MemoryMaleMonocytesSARS-CoV-2T-LymphocytesTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.