ArticleNature2025
Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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77citing papers in PubMed
–field-weighted citation impact
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The trial behind it
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Who cites it
77 citing papers in PubMed.
- Advances in pharmacological interventions for hepatic fibrosis: from pathogenic mechanisms to novel therapeutic targets.Annals of medicine · 2026Review
- THBS1+ macrophages fuel pathogenic inflammation in alcohol-associated liver disease.Hepatology communications · 2026Article
- ITGBL1-MYH9 interaction in hepatic stellate cells acts as a mechanoregulator controlling liver fibrosis in mice.The Journal of clinical investigation · 2026Article
- Hepatic stellate cell subpopulations in human MASLD-related hepatocellular carcinoma upregulate YAP via geranylgeranyl pyrophosphate.Hepatology communications · 2026Article
- Matrix stiffness shapes early transcriptional trajectories during hepatic stellate cell activation.Hepatology international · 2026Article
- JMJD3-mediated HADH demethylation orchestrates hepatocyte maturation through fatty acid β-oxidation-dependent histone acetylation.Experimental & molecular medicine · 2026Article
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Article
- Haemodynamic control of zonated liver function via instructive vascular Wnt signalling.Nature communications · 2026Article
- The Isolation and Characterization of ACE Inhibitory Peptides fromFoods (Basel, Switzerland) · 2026Article
- Succinic acid inhibits hepatocyte regenerative signaling via STAT3 SH2-domain engagement.Molecular biomedicine · 2026Article
- Leveraging IGF signaling to improve the spatial organization and regenerative potential of iPSC-derived vascularized liver organoids.Science advances · 2026Article
- MASLD: Spatial Mechanisms and New Therapeutics.Biomolecules · 2026Review
- TGFβ activity stabilizes ACC1 to increase de novo lipogenesis in metabolic liver disease.Molecular metabolism · 2026Article
- p21-activated kinase 4 drives hepatic stellate cell activation and liver fibrosis through the phosphorylation of YAP at T428.Signal transduction and targeted therapy · 2026Article
- Spatial transcriptomics differences of histopathological growth patterns in colorectal cancer liver metastases.British journal of cancer · 2026Article
- LYNX: a deep generative model for linking spatial dynamics and cell interactions in multimodal spatial data.bioRxiv : the preprint server for biology · 2026Article
- Shared mechanisms of organ fibrosis.JCI insight · 2026Review
- Fibroblasts: a diverse population of cells balancing homeostasis, wound healing, regeneration, inflammation, fibrosis, and cancer across organs.JCI insight · 2026Review
- Vascularized Liver-on-a-Microsphere Reveals Alanine-Glucose Metabolism-Driven Regulation of Liver Function and Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors.
Atsushi Sugimoto *Department of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0003-3311-2562
Yoshinobu Saito *Department of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-0624-0449
Guanxiong Wang *Division of Vascular Oncology and Metastasis Research, German Cancer Research Center, Heidelberg, Germany.
Qiuyan SunDepartment of Medicine, Columbia University, New York, NY, USA.
Chuan YinDepartment of Medicine, Columbia University, New York, NY, USA.
Ki Hong LeeDivision of Vascular Oncology and Metastasis Research, German Cancer Research Center, Heidelberg, Germany.ORCID 0009-0004-3640-4944
Yana GengDepartment of Medicine, Columbia University, New York, NY, USA.
Presha RajbhandariDepartment of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA.ORCID 0000-0003-2184-7238
Celine HernandezDepartment of Medicine, Columbia University, New York, NY, USA.
Marcella SteffaniDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-7439-7851
Jingran QieDepartment of Medicine, Columbia University, New York, NY, USA.
Thomas SavageDepartment of Microbiology & Immunology, Columbia University, New York, NY, USA.ORCID 0000-0002-6618-2973
Dhruv M GoyalDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0009-0007-6454-2158
Kevin C RayDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Taruna V NeelakantanDepartment of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA.
Deqi YinDepartment of Medicine, Columbia University, New York, NY, USA.
Johannes MelmsDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-5410-6586
Brandon M LehrichDepartment of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Tyler M YasakaDepartment of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-8482-0369
Silvia LiuDepartment of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Michael OertelDepartment of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Tian LanDepartment of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Adrien GuillotDepartment of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6002-9986
Moritz PeiselerDepartment of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Aveline FilliolDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-1345-8147
Hiroaki KanzakiLiver Tumour Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Naoto FujiwaraLiver Tumour Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Samhita RaviDivision of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-6731-734X
Benjamin IzarDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0003-2379-6702
Mario BroschDepartment of Internal Medicine I, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Jochen HampeDepartment of Internal Medicine I, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Helen RemottiColumbia University Digestive and Liver Disease Research Center, New York, NY, USA.
Josepmaria ArgemiLiver Unit and RNA Biology and Therapies Program, Cima Universidad de Navarra, Cancer Center Clínica Universidad de Navarra (CCUN), Pamplona, Spain.ORCID 0000-0003-1696-7753
Zhaoli SunDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timothy J KendallInstitute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4174-2786
Yujin HoshidaLiver Tumour Translational Research Program, Harold C. Simmons Comprehensive Cancer Center, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-9430-1426
Frank TackeDepartment of Hepatology & Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-6206-0226
Jonathan A FallowfieldInstitute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-5741-1471
Storm K Blockley-PowellDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0009-0009-8519-9904
Rebecca A HaeuslerDepartment of Medicine, Columbia University, New York, NY, USA.ORCID 0000-0002-6973-9845
Jonathan B SteinmanDepartment of Pediatrics, Columbia University, New York, NY, USA.
Utpal B PajvaniDepartment of Medicine, Columbia University, New York, NY, USA.
Satdarshan P MongaDepartment of Pharmacology and Chemical Biology, Pittsburgh Liver Research Center, and Organ Pathobiology and Therapeutics Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID 0000-0002-8437-3378
Ramon BatallerLiver Unit,Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain.
Mojgan MasoodiInstitute of Clinical Chemistry, Inselspital, Bern University Hospital, Bern, Switzerland.
Nicholas ArpaiaColumbia University Digestive and Liver Disease Research Center, New York, NY, USA.ORCID 0000-0002-0657-0528
Youngmin A LeeDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Brent R StockwellColumbia University Digestive and Liver Disease Research Center, New York, NY, USA.ORCID 0000-0002-3532-3868
Hellmut G AugustinDivision of Vascular Oncology and Metastasis Research, German Cancer Research Center, Heidelberg, Germany. augustin@angioscience.de.ORCID 0000-0002-7173-4242
Robert F SchwabeDepartment of Medicine, Columbia University, New York, NY, USA. rfs2102@cumc.columbia.edu.ORCID 0000-0003-4571-2098
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6MTumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MProject 4-Early Liver Transplantation for Severe Alcoholic Hepatitis: Animal StudiesP50AA027054 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI ANDREW M. CAMERON · 2019 to 2026
$15.1MPittsburgh Liver Research CenterP30DK120531 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Shuchang Silvia Liu · 2019 to 2026
$10.9MRole of Wnt/Beta-Catenin Signaling in Liver DevelopmentR01DK062277 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Satdarshan Singh Monga · 2004 to 2026
$9.0MThe Organoid and Cell Culture CoreP30DK132710 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Robert F. Schwabe · 2022 to 2026
$7.2MCellular Approaches to Tissue Engineering/RegenerationT32EB001026 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN, ANDREW W, MONGA, SATDARSHAN SINGH · 2003 to 2024
$5.5MBile acids and insulin sensitivityR01DK115825 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rebecca Anne Haeusler · 2018 to 2026
$5.4MTrial of Statins for Chemoprevention in Hepatocellular CarcinomaR01CA255621 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, RAYMOND T, HOSHIDA, YUJIN · 2021 to 2025
$3.6MReverse-engineering precision liver cancer chemopreventionR01CA233794 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HOSHIDA, YUJIN · 2019 to 2023
$3.5MNCI NIH HHS P30 CA013696NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA233794NCI NIH HHS R01 CA250227NCI NIH HHS R01 CA251155NCI NIH HHS R01 CA255621NCI NIH HHS R01 CA262424NCI NIH HHS R01 CA282178NIAAA NIH HHS P50 AA027054NIAMS NIH HHS R01 AR082388NIBIB NIH HHS T32 EB001026NIDDK NIH HHS P30 DK058404NIDDK NIH HHS P30 DK120531NIDDK NIH HHS P30 DK132710NIDDK NIH HHS R01 DK062277NIDDK NIH HHS R01 DK115825NIDDK NIH HHS R01 DK128955NIDDK NIH HHS R01 DK133512NIDDK NIH HHS R24 DK139775
Abstract
Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood
Indexed as
Hepatic Stellate CellsLiverR-SpondinsAnimalsFatty LiverFemaleHepatocytesHumansLiver RegenerationMaleMiceOrgan SizeThrombospondinsWnt Signaling PathwayRSPO3 protein, humanR-spondin3 protein, mouseR-SpondinsThrombospondins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.