Evidence map›Paper›PMID 40074806›Full record

ArticleScientific reports2025

Multi-omics analysis revealed the novel role of NQO1 in microenvironment, prognosis and immunotherapy of hepatocellular carcinoma.

Ya Tang, Haihong Hu, Siyuan Chen, Bo Hao, Xuefeng Xu, Hongxia Zhu, Wendi Zhan, Taolan Zhang, Hongjuan Hu, Guodong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ya Tang *School of Public Health, Hengyang Medical College, University of South China, 28 Western Changsheng Road, Hengyang, 421001, Hunan, China.
Haihong Hu *Department of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Siyuan Chen *Department of Breast and Thyroid Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Bo HaoDepartment of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Xuefeng XuDepartment of Function, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Hongxia ZhuDepartment of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Wendi ZhanDepartment of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Taolan ZhangDepartment of Pharmacy, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. TaolZhan@usc.edu.cn.
Hongjuan HuDepartment of Public Health Service, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421000, Hunan, China. huhongjuan1114@163.com.
Guodong ChenDepartment of Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China. chenguodong@usc.edu.cn.

Funding

Central Government Guided Local Science and Technology Development Fund Project in Xinjiang Uygur Autonomous Region ZYYD2024CG17Health Technology Promotion Project in Xinjiang Uygur Autonomous Region SYTG-Y202429Hunan Province Innovation Ecological Construction Plan Science and Technology Assistance Project in Xinjiang Uygur Autonomous Region 2024WK4008National Natural Science Foundation of China 82473965Natural Science Foundation of Hunan Province 2024JJ7455Science and technology innovation Program of Hengyang City 202250045223the Natural Science Foundation of Hunan Province 2023JJ50156the Scientific Research Project of the Hunan Provincial Department of Education 24B0413University of South China Clinical Research 4310 Program 20224310NHYCG01University of South China Clinical Research 4310 Program 20224310NHYCG04
6 · The paper itself

Abstract

NAD(P)H dehydrogenase quinone 1 (NQO1) is overexpressed in various cancers and is strongly associated with an immunosuppressive microenvironment and poor prognosis. In this study, we explored the role of NQO1 in the microenvironment, prognosis and immunotherapy of Hepatocellular carcinoma (HCC) using multi-omics analysis and machine learning. The results revealed that NQO1 was significantly overexpressed in HCC cells. NQO1

Indexed as

Carcinoma, HepatocellularImmunotherapyLiver NeoplasmsNAD(P)H Dehydrogenase (Quinone)Tumor MicroenvironmentCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMultiomicsNomogramsPrognosisTumor-Associated MacrophagesNAD(P)H Dehydrogenase (Quinone)NQO1 protein, humanHepatocellular carcinomaImmunotherapyNQO1PrognosisTumor microenvironment

Identifiers

PMID40074806
PMCPMC11903666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.