Evidence map›Paper›PMID 40074779›Full record

ArticleScientific reports2025

Endocardial-to-mesenchymal transition underlies cardiac outflow tract septation and bicuspid aortic valve formation in the Syrian hamster model.

María Teresa Soto-Navarrete, Bárbara Pozo-Vilumbrales, Miguel Á López-Unzu, Laura Martín-Chaves, Ana C Durán, Borja Fernández

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

María Teresa Soto-NavarreteDepartment of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain.
Bárbara Pozo-VilumbralesDepartment of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain.
Miguel Á López-UnzuSpanish National Centre for Cardiovascular Research (CNIC), Madrid, Spain.
Laura Martín-ChavesBiomedical Research Institute of Malaga and Nanomedicine Platform-IBIMA BIONAND Platform, Malaga, Spain.
Ana C DuránDepartment of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain.
Borja FernándezDepartment of Animal Biology, Faculty of Science, University of Malaga, Malaga, Spain. borjafe@uma.es.

Funding

Consejería de Economía y Conocimiento UMA20-FEDERJA-041Consejería de Salud y Consumo, Junta de Andalucía PI-0530-2019Consejería de Universidad, Investigación e Innovación PROYEXCEL_01009II Plan Propio de Investigación, Transferencia y Divulgación Científica de la Universidad de Málaga Contrato PuenteMinisterio de Ciencia e Innovación CGL2017-85090-PMinisterio de Ciencia e Innovación FJC2021 047055-IMinisterio de Ciencia e Innovación PRE2018-083176
6 · The paper itself

Abstract

Right-left bicuspid aortic valve (R-L BAV) is the most frequent phenotype of the most common congenital heart disease. Its etiology is based on two associated morphogenetic defects during cardiac outflow tract (OFT) septation: abnormal migration of cardiac neural crest (CNC) cells, and excessive fusion of the conal ridges (CRs). The aim of this study is to elucidate the mechanism involved in the fusion of the CRs responsible for normal and abnormal OFT septation and BAV formation. Two mechanisms have been proposed: endocardial apoptosis and endocardial-mesenchymal transition (EMT). The involvement of these mechanisms in the fusion event was tested in embryos of the hamster model with BAV. Apoptotic cells were absent in the fusion area of the CRs. However, we detected endocardial cells (CD34

Indexed as

Aortic ValveEndocardiumEpithelial-Mesenchymal TransitionHeart Valve DiseasesAnimalsApoptosisBicuspid Aortic Valve DiseaseCell MovementCricetinaeDisease Models, AnimalMesocricetusNeural CrestBicuspid aortic valveCardiac outflow tractEndocardial cushion fusionEndocardial-mesenchymal transitionHamster embryo

Identifiers

PMID40074779
PMCPMC11903957

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.