Evidence map›Paper›PMID 40074774›Full record

ArticleScientific reports2025

Malabaricone C isolated from edible plants as a potential inhibitor of SARS-CoV-2 infection.

Mutmainah, Yuta Murai, Ai Fujimoto, Rintaro Kawamura, Akira Kitamura, Sajeer Koolath, Seigo Usuki, Michihito Sasaki, Yasuko Orba, Yasuyuki Igarashi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

MutmainahGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Yuta MuraiGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan. ymurai@agr.hokudai.ac.jp.
Ai FujimotoGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Rintaro KawamuraGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Akira KitamuraGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Sajeer KoolathGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Seigo UsukiFaculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Michihito SasakiInternational Institute for Zoonosis Control, Hokkaido University, Kita 20 Nishi 10, Kita-Ku, Sapporo, 001-0020, Japan.
Yasuko OrbaInternational Institute for Zoonosis Control, Hokkaido University, Kita 20 Nishi 10, Kita-Ku, Sapporo, 001-0020, Japan.
Yasuyuki IgarashiFaculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan.
Hirofumi SawaInternational Institute for Zoonosis Control, Hokkaido University, Kita 20 Nishi 10, Kita-Ku, Sapporo, 001-0020, Japan.
Akihiko SatoInternational Institute for Zoonosis Control, Hokkaido University, Kita 20 Nishi 10, Kita-Ku, Sapporo, 001-0020, Japan. akihiko.sato@shionogi.co.jp.
Kenji MondeGraduate School of Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-Ku, Sapporo, 001-0021, Japan. kmonde@sci.hokudai.ac.jp.

Funding

a Grant-in-Aid for Scientific Research KAKENHI 24K08626, 24K21815the Japan Agency for Medical Research and Development (AMED) JP243fa627005the Japan Agency for Medical Research and Development (AMED) JP243fa627005, JP23wm0125008
6 · The paper itself

Abstract

Although the SARS-CoV-2 epidemic worldwide has gradually decreased, in some areas, the situation has not yet been stamped and has become a global health emergency. It is quite possible that we could again be threatened by a new coronavirus. Therefore, new nucleotide analog drugs and vaccines or using drug repositioning for SARS-CoV-2 still has been developed, yet their safety and efficacy against COVID-19 remains underexplored. Malabaricone C is 2,6-dihydroxyphenyl acylphenol found in edible plants such as the mace spice of nutmeg derived from the seeds of Myristica fragrans. In this study, we identified malabaricone C as the first inhibitor of SARS-CoV-2 from natural food with a safe alternative for drugs. Malabaricone C and its chemical derivatives showed EC

Indexed as

Antiviral AgentsCOVID-19 Drug TreatmentPlants, EdibleSARS-CoV-2AnimalsChlorocebus aethiopsCOVID-19HEK293 CellsHumansVero CellsVirus InternalizationAntiviral Agents

Identifiers

PMID40074774
PMCPMC11903690

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.