ArticleNature communications2025
Salt stress activates the CDK8-AHL10-SUVH2/9 module to dynamically regulate salt tolerance in Arabidopsis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- OsbZIP60 Positively Regulates Salt-Stress Tolerance in Rice.International journal of molecular sciences · 2026Article
- CRISPR/Cas9-Mediated Knockout of LbSP1 and LbSP5G1 Reveals Efficient Customization of Shoot Architecture in Black Goji Berry.Plant biotechnology journal · 2026Article
- Genome-Wide Characterization and Salt-Responsive Expression Divergence of Chromosome Group 2 and Group 6Plants (Basel, Switzerland) · 2026Article
- Abscisic acid-regulated stability of CmABF1 and CmBRM modulates salt tolerance in chrysanthemum via epigenetic regulation ofScience advances · 2026Article
- Engineering climate-resilient horticultural crops: advances in transcriptional regulation, genome editing, and synthetic networks.Horticulture research · 2026Article
- Genome-Wide Identification, Expression and Tissue-Specific Epigenetic Modification Analysis of theBiology · 2026Article
- Whole-Genome Analysis of the Cell Cycle Regulators in Soybean: Evolution, Expansion, and Functional Implications.Biology · 2026Article
- Recent Advances in Histone Methylation in Plant Adaptation to Salinity.Plants (Basel, Switzerland) · 2026Review
- Nuclear Proteomics to Understand the Promotive Effect of Plant-Derived Smoke Solution on Wheat Under Salt Stress.Proteomes · 2026Article
- A Truncated WRKY Protein Enhances Drought Resistance in Wild Tomatoes Through the SlWRKY16-CIP2b-SlSYP121 Module.Plant biotechnology journal · 2026Article
- Identifying candidate genes related to rice ML under salt-alkali tolerance.BMC plant biology · 2026Article
- CRISPR-enhanced microalgae biosynthesis: a promising approach for future functional feed ingredients.Journal of animal science and biotechnology · 2026Review
- Characterization of tomato AHL proteins and their biological functions in the resistance to salt and osmotic stresses.Plant cell reports · 2026Article
- Direct receptor competition gates RGL2 proteolysis for seed germination timing in Arabidopsis.The EMBO journal · 2026Article
- Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition.JCI insight · 2026Article
- PfTALE5 Acts as a hub for multi-stress resilience: a genome-wide study of the TALE family in Paulownia fortunei.BMC plant biology · 2026Article
- Global change-driven plant adaptive strategies and interspecific interaction networks: from molecular regulation to ecological management.Frontiers in plant science · 2026Review
- Progress in Molecular Plant Science (2023-2025).Current issues in molecular biology · 2025Article
- Emerging Mechanisms of Plant Responses to Abiotic Stress.Plants (Basel, Switzerland) · 2025Review
- Epigenetics in Plant Response to Climate Change.Biology · 2025Review
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6 authors.
Funding
Abstract
Salt stress has devastating effects on agriculture, yet the key regulators modulating the transcriptional dynamics of salt-responsive genes remain largely elusive in plants. Here, we discover that salt stress substantially induces the kinase activity of Mediator cyclin-dependent kinase 8 (CDK8), which is essential for its positive role in regulating salt tolerance. CDK8 is identified to phosphorylate AT-hook motif nuclear-localized protein 10 (AHL10) at serine 314, leading to its degradation under salt stress. Consistently, AHL10 is found to negatively regulate salt tolerance. Transcriptome analysis further indicates that CDK8 regulates over 20% of salt-responsive genes, half of which are co-regulated by AHL10. Moreover, AHL10 is revealed to recruit SU(VAR)3-9 homologs (SUVH2/9) to AT-rich DNA sequences in the nuclear matrix-attachment regions (MARs) of salt-responsive gene promoters, facilitating H3K9me2 deposition and repressing salt-responsive genes. Our study thereby has identified the CDK8-AHL10-SUVH2/9 module as a key molecular switch controlling transcriptional dynamics in response to salt stress.
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