ArticleRenal failure2025
Utilization of lactate trajectory models for predicting acute kidney injury and mortality in patients with hyperlactatemia: insights across three independent cohorts.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Lactate in acute kidney injury: pathobiology, risk stratification, and clinical interpretation.Renal failure · 2026Review
- Advancements in early biomarkers of acute kidney injury: from traditional indicators to a paradigm shift in lactate metabolism.Annals of medicine · 2026Review
- Association Between Lactate Trajectories and Clinical Outcomes in Critically Ill Patients with Sepsis-Associated Liver Injury.Journal of clinical medicine · 2026Article
- Research on Sepsis and Metabolic Reprogramming from 1998 to 2025: A Bibliometric and Visualized Analysis.Shock (Augusta, Ga.) · 2026Article
- Critical care considerations in rhabdomyolysis-associated acute kidney injury and kidney replacement therapy.World journal of nephrology · 2026Review
- Blood biomarker trajectories in ICU-directed prediction models - A scoping review.The EPMA journal · 2026Review
- Lactate trajectories and outcomes in critically ill patients with septic shock: a retrospective analysis of the MIMIC-IV database.BMC medical informatics and decision making · 2026Article
- Postoperative lactate trajectories predict in-hospital adverse outcomes and differ by surgical approach in cardiac surgery: a propensity score-matched study.Frontiers in cardiovascular medicine · 2026Article
- Explainable AI identifies key biomarkers for acute kidney injury prediction in the ICU.Intensive care medicine experimental · 2025Article
- The new insights of lactate in various kidney diseases.Expert reviews in molecular medicine · 2025Review
- Predicting outcomes in pediatric patients with acute kidney injury: a retrospective single-center cohort study using machine learning models.BMC medical informatics and decision making · 2025Article
- Predicting Acute Kidney Injury in Acute Rhabdomyolysis.Journal of clinical medicine · 2025Article
- Identification of the risk factors for predicting severe acute kidney injury in patients after liver transplantation.Frontiers in physiology · 2025Article
- Association between lactate trajectory and 30-day mortality in patients with acute kidney injury and delirium: A retrospective study.Science progressArticle
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Authors and funding
7 authors.
Funding
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Abstract
This study aims to investigate the association between lactate trajectories and the risk of acute kidney injury (AKI) and hospital mortality in patients with hyperlactatemia. We conducted a multicenter retrospective study using data from three independent cohorts. By the lactate levels during the first 48 h of ICU admission, patients were classified into distinct lactate trajectories using group-based trajectory modeling (GBTM) method. The primary outcomes were AKI incidence and hospital mortality. Logistic regression analysis assessed the association between lactate trajectories and clinical outcomes, with adjusting potential confounders. Patients were divided into three trajectories: mild hyperlactatemia with rapid recovery (Traj-1), severe hyperlactatemia with gradual recovery (Traj-2), and severe hyperlactatemia with persistence (Traj-3). Traj-3 was an independent risk factor of both hospital mortality (all
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