Boron in My Mind: A Comprehensive Review of the Evolution of the Diverse Syntheses of 4-Borono-l-Phenylalanine, the Leading Agent for Boron Neutron Capture Therapy.

Sarfraz Ahmad, Ming Pan, John J Hayward, Massimo Sementilli, Lisa A Porter, John F Trant

Abstract readReview

In one paragraph

Review in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarfraz AhmadDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON, N9B 3P4, Canada.ORCID https://orcid.org/0000-0003-0059-477X

Ming PanWindsor Regional Hospital, Windsor, ON, N8W 1L9, Canada.ORCID https://orcid.org/0000-0003-2313-6827

John J HaywardDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON, N9B 3P4, Canada.ORCID https://orcid.org/0000-0002-7502-7780

Massimo SementilliDepartment of Biomedical Sciences, University of Windsor, Windsor, ON, N9B 3P4, Canada.

Lisa A PorterDepartment of Biomedical Sciences, University of Windsor, Windsor, ON, N9B 3P4, Canada.ORCID https://orcid.org/0000-0002-9234-1712

John F TrantDepartment of Chemistry and Biochemistry, University of Windsor, Windsor, ON, N9B 3P4, Canada.ORCID https://orcid.org/0000-0002-4780-4968

Funding

Natural Sciences and Engineering Research Council of Canada 2018-06338

6 · The paper itself

Abstract

Boron neutron capture therapy leverages the nuclear reaction between boron-10 and thermal neutrons to selectively destroy cancer cells while minimizing damage to surrounding healthy tissues. This therapy finds use in treating glioblastoma, which, as a brain cancer, is difficult to treat using conventional radiotherapy, surgery, and chemotherapy due to location and the risk of brain damage. However, to work, the cells must contain

Indexed as

BoronBoron CompoundsBoron Neutron Capture TherapyPhenylalanineHumansMolecular StructureBoronBoron CompoundsPhenylalanine4‐borono‐l‐phenylalanines (l‐BPAs)boron neutron capture therapies (BNCTs)cancersglioblastomas

Identifiers

PMID40074685

DOI10.1002/cmdc.202500059

PMCPMC12132916

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.