ArticleJournal of sleep research2025
Sleep Health and White Matter Integrity in the UK Biobank.
Article in Journal of sleep research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Insomnia With Objective Short Sleep Duration Is Associated With Incident Cardiovascular and Cerebrovascular Disease: Evidence from the UK Biobank Data.Journal of the American Heart Association · 2026Article
- Striatum volume and affective symptomatology are associated with sleep in schizophrenia.Journal of psychiatric research · 2026Article
- Sleep Health and White Matter Integrity in the UK Biobank.Journal of sleep research · 2025Article
- Exploratory GABAa-informed control network modulates hyperarousal brain dynamics in chronic insomnia.Communications biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many people experience impaired sleep health, yet knowledge about its neurobiological correlates is limited. As previous studies have found associations between white matter integrity and several sleep traits, white matter integrity could be causally implicated in poor sleep health. However, these studies were often limited by small sample sizes. In this study, we examine associations between multiple indices of white matter integrity and sleep health in 29,114 UK Biobank participants. Late chronotype, daytime sleepiness, insomnia symptoms and, most extensively, long sleep duration were independently associated with diffusion MRI markers of reduced white matter integrity. Previous findings showing an association between insomnia symptoms and decreased fractional anisotropy (FA) in the anterior internal capsule could not be replicated. To our knowledge, the current analysis is the first study to find an association between long sleep duration and impaired microstructural white matter integrity. Previous assumptions concerning the role of white matter integrity for insomnia are challenged.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.