Evidence map›Paper›PMID 40074447›Full record

ArticleJournal, genetic engineering & biotechnology2025

MEFV gene variations in COVID-19 pneumonia patients (Pilot study).

Noha A Radwan, Heba El Gohary, Dalia Hamed, Noha M Khalil, Dalia Abdelfatah, Amal Abdel Wahab, Marwa Mahmoud Elsharkawy

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Article in Journal, genetic engineering & biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Noha A RadwanDepartement of Clinical and Chemical Pathology, Kasr Alainy Medical School, Cairo University, Egypt. Electronic address: nohakhaled11@cu.edu.eg.
Heba El GoharyDepartement of Clinical and Chemical Pathology, Kasr Alainy Medical School, Cairo University, Egypt.
Dalia HamedDepartement of Clinical and Chemical Pathology, Kasr Alainy Medical School, Cairo University, Egypt.
Noha M KhalilDepartment of Internal Medicine, Kasr Alainy Medical School, Cairo University, Egypt.
Dalia AbdelfatahCancer Epidemiology and Biostatistics Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Amal Abdel WahabDepartement of Clinical and Chemical Pathology, Kasr Alainy Medical School, Cairo University, Egypt.
Marwa Mahmoud ElsharkawyDepartement of Clinical and Chemical Pathology, Kasr Alainy Medical School, Cairo University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe emergence of worldwide pandemic caused by coronavirus 2 (SARS-CoV-2) has caused a radical change in everyday life. Patients diseased with FMF show manifestations and labs highly similar to COVID infected patients. In the current study, we evaluate the presence of variants in exon 10 of MEFV gene and the relation with severity of symptoms in patients with COVID-19 pneumonia.

methodThirty-nine COVID-19 infected patients admitted to Kasr Alainy medical school were divided into two groups moderate and severe. Sanger sequencing of exon 10 in MEVF gene was scanned in the 39 subjects.

resultsWe identified variants in 10 out of 39 patients (26 %) with heterozygous variants in 9 patients (23 %) and homozygous in one patient (2.5 %). The most frequent variant found was the silent variant p.(P706 = ) (12.9 %) followed by missense variants p.(A744S) (7.7 %) and p.(V726A) (5.1 %). Striking result was that 90 % of patients with MEFV variants had moderate symptoms and without progression into the severe form of COVID-19 pneumonia.

conclusionOur results indicated that the presence of variants in MEFV gene (either benign or of uncertain significance) could have a role in determination of COVID-19 severity.

Indexed as

ARDSCOVID-19MEFV geneSanger Sequencing

Identifiers

PMID40074447
PMCPMC11926684

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