Evidence map›Paper›PMID 40074360›Full record

ArticleJournal of atherosclerosis and thrombosis2025

Association of Life's Essential 8 Scores with Carotid Artery Plaque in Chinese Adults: A Prospective Cohort Study.

Ping Yu, Dong-Yu Wu, Xiao-Wei Fan, Xue Tian, An-Xin Wang, Yong Jiang, Wei-Guo Ma, Ning Zhang, Chun-Xue Wang

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Article in Journal of atherosclerosis and thrombosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ping YuBeijing Tiantan Hospital, Capital Medical University, Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Sleep Center.
Dong-Yu WuBeijing Tiantan Hospital, Capital Medical University, Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Sleep Center.
Xiao-Wei FanBeijing Tiantan Hospital, Capital Medical University, Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Sleep Center.
Xue TianBeijing Tiantan Hospital, Capital Medical University, Department of Neurology.
An-Xin WangBeijing Tiantan Hospital, Capital Medical University, Department of Neurology.
Yong JiangBeijing Tiantan Hospital, Capital Medical University, Department of Neurology.
Wei-Guo MaBeijing Anzhen Hospital.
Ning ZhangBeijing Tiantan Hospital, Capital Medical University, Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Sleep Center.
Chun-Xue WangBeijing Tiantan Hospital, Capital Medical University, Department of Neuropsychiatry and Behavioral Neurology and Clinical Psychology, Sleep Center.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe American Heart Association (AHA) proposed Life's Essential 8 score (LE8) in 2022 as a new metric for cardiovascular health (CVH). This study investigated the association between the LE8 score and the development of carotid artery plaque.

methodsData were drawn from the Asymptomatic Polyvascular Abnormalities Community (APAC) cohort study. In 2010, 1,938 participants without carotid plaques were recruited and followed-up until 2012. LE8 scores ranging from 0 to 100 were categorized as low (0-49), moderate (50-79), and high (80-100), whereas carotid plaques were measured using color Doppler ultrasound. A logistic analysis was used to analyze the association between the LE8 score and carotid plaque.

resultsDuring the 2-year follow up period, 350 (18.1%) patients developed new carotid plaques. The incidence of newly developed carotid plaques decreased from 27.0% in the low-LE8 group to 13.7% in the high-LE8 group (p＜0.001). Adjusted odds ratios (ORs) for plaque development were 0.65 (95% confidence interval [CI], 0.45-0.93) in the moderate-LE8 group and 0.55 (95% CI, 0.34-0.90) in the high-LE8 group compared to the low-LE8 group. Higher LE8 scores were associated with a lower risk of stable and multiple carotid plaques.

conclusionsAn elevated LE8 score was associated with a lower risk of carotid plaque formation as well as plaque stability and quantity. Promoting adherence to optimal CVH levels may be beneficial in reducing the burden of carotid plaques and the risk of cardiovascular disease.

Indexed as

Carotid Artery DiseasesCarotid StenosisPlaque, AtheroscleroticAgedChinaEast Asian PeopleFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPrognosisProspective StudiesRisk AssessmentRisk FactorsAtherosclerosisCerebrovascular disordersPlaque

Identifiers

PMID40074360
PMCPMC12416954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.