Evidence map›Paper›PMID 40073932›Full record

ArticleJournal of molecular and cellular cardiology2025

Myosin-actin crossbridge independent sarcomere length induced Ca

Xutu Wang, R John Solaro, Wen-Ji Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Evidence for a role of adverse sarcomere signaling in atrial fibrillation induction.Journal of molecular and cellular cardiology plus · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xutu WangVoiland School of Chemical and Bioengineering, Washington State University, Pullman, WA 99163-1062, USA.
R John SolaroDepartment of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612-7342, USA.
Wen-Ji DongVoiland School of Chemical and Bioengineering, Washington State University, Pullman, WA 99163-1062, USA; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99163-1062, USA. Electronic address: dongwenji@wsu.edu.

Funding

Kinetics of Cardiac Myofilament ActivationR01HL080186 · NHLBI · WASHINGTON STATE UNIVERSITY · PI DONG, WEN-JI · 2005 to 2013
$3.4M
Structural Kinetics of Thin Filament Regulation at Single Molecule LevelR21HL109693 · NHLBI · WASHINGTON STATE UNIVERSITY · PI DONG, WEN-JI · 2013 to 2014
$388k
NHLBI NIH HHS R01 HL080186NHLBI NIH HHS R21 HL109693
6 · The paper itself

Abstract

Sarcomere length-dependent activation (LDA) is essential to engaging the Frank-Starling mechanism in the beat-to-beat regulation of cardiac output. Through LDA, the heart increases the Ca

Indexed as

ActinsCalciumMyocardiumMyosinsSarcomeresAnimalsMyocardial ContractionRatsTroponin CTroponin IActinsCalciumMyosinsTroponin CTroponin ICa(2+) sensitivityCardiac muscleLength dependent activationMyosin-actin cross-bridgeMyosin-troponin interactionSkinned myocardial fibersTroponin CTroponin ITroponin T

Identifiers

PMID40073932
PMCPMC13224722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.