Evidence map›Paper›PMID 40073863›Full record

ArticleCell reports2025

Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection.

Asgar Ansari, Shilpa Sachan, Jatin Ahuja, Sureshkumar Venkadesan, Bhushan Nikam, Vinod Kumar, Shweta Jain, Bhanu Pratap Singh, Poonam Coshic, Kapil Sikka and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Dengue and severe dengue.Clinical microbiology reviews · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Asgar AnsariVaccine Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India.
Shilpa SachanVaccine Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India.
Jatin AhujaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Sureshkumar VenkadesanBioinformatics Center, National Institute of Immunology, New Delhi 110067, India.
Bhushan NikamVaccine Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India.
Vinod KumarDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Shweta JainDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Bhanu Pratap SinghVaccine Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India.
Poonam CoshicDepartment of Transfusion Medicine, AIIMS, New Delhi 110029, India.
Kapil SikkaDepartment of Otorhinolaryngology, Head and Neck Surgery, AIIMS, New Delhi 110029, India.
Naveet WigDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Alessandro SetteCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Daniela WeiskopfCenter for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA.
Debasisa MohantyBioinformatics Center, National Institute of Immunology, New Delhi 110067, India.
Manish SonejaDepartment of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.
Nimesh GuptaVaccine Immunology Laboratory, National Institute of Immunology, New Delhi 110067, India. Electronic address: nimesh.gupta@nii.ac.in.

Funding

Identifying mechanisms and correlates of long-lasting vaccine-induced immunity to whooping coughU01AI141995 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI PETERS, BJOERN, SETTE, ALESSANDRO · 2019 to 2023
$4.1M
NIAID NIH HHS U01 AI141995
6 · The paper itself

Abstract

Dengue-virus-induced humoral immunity can increase the risk of severe disease, but the factors influencing this response are poorly understood. Here, we investigate the contribution of CD4

Indexed as

B-LymphocytesDengueDengue VirusT-Lymphocytes, Helper-InducerAdultFemaleHumansImmunity, HumoralInterleukin-21InterleukinsMaleInterleukin-21Interleukinsantibody responseCP: ImmunologyCP: Microbiologydengueextrafollicular B cellshumoral immunityIL-21PD-1(+) T helpersingle-cell transcriptomicsT cell-B cell collaborationT cell clonotypesT follicular helper

Identifiers

PMID40073863
PMCPMC12032839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.