Evidence map›Paper›PMID 40073421›Full record

ArticleChemMedChem2025

Significant Tumor Inhibition of Trimethyl-15

Anita Benić, Akmaral Kussayeva, Ivana Antol, Mario Vazdar, Zlatko Brkljača, Dan-Ye Chen, Yi-Jia Yan, Ying-Hua Gao, Zhi-Long Chen, Davor Margetić

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anita BenićDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, Zagreb, 10000, Croatia.
Akmaral KussayevaDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, Zagreb, 10000, Croatia.
Ivana AntolDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, Zagreb, 10000, Croatia.
Mario VazdarDepartment of Mathematics, Informatics and Cybernetics, University of Chemistry and Technology, 16628, Prague, Czech Republic.
Zlatko BrkljačaDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, Zagreb, 10000, Croatia.
Dan-Ye ChenDepartment of Pharmaceutical Science & Technology, Donghua University, Shanghai, 201620, China.
Yi-Jia YanDepartment of Pharmaceutical Science & Technology, Donghua University, Shanghai, 201620, China.
Ying-Hua GaoDepartment of Pharmaceutical Science & Technology, Donghua University, Shanghai, 201620, China.
Zhi-Long ChenDepartment of Pharmaceutical Science & Technology, Donghua University, Shanghai, 201620, China.
Davor MargetićDivision of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička c. 54, Zagreb, 10000, Croatia.

Funding

Croatian Science Foundation IP-2022-10-4385Ministry of Science and Technology of China 10-6Ministry of Science and Technology of China 9-11National Natural Science Foundation of China 22361132541National Natural Science Foundation of China 82203043RSF 24-45-00020Shanghai Science and Technology Committee 21430730100Shanghai Science and Technology Committee 21MC1930200Shanghai Science and Technology Committee 23S11901600
6 · The paper itself

Abstract

A novel pheophorbide derivative, trimethyl-15

Indexed as

Antineoplastic AgentsChlorophyllPhotochemotherapyPhotosensitizing AgentsAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMiceMolecular Dynamics SimulationMolecular StructureReactive Oxygen SpeciesAntineoplastic AgentsChlorophyllpheophorbide aPhotosensitizing AgentsReactive Oxygen Speciescancerkeyword 5molecular dynamicspheophorbidephotodynamic therapy

Identifiers

PMID40073421
PMCPMC12091846

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.