Evidence map›Paper›PMID 40073368›Full record

ArticleOncotarget2025

Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients.

Wafik S El-Deiry, Catherine Bresson, Fanny Wunder, Benedito A Carneiro, Don S Dizon, Jeremy L Warner, Stephanie L Graff, Christopher G Azzoli, Eric T Wong, Liang Cheng and 77 more

Abstract read
In one paragraph

Article in Oncotarget, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

87 authors.

Wafik S El-DeiryWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
Catherine BressonWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
Fanny WunderWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
Benedito A CarneiroLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Don S DizonLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Jeremy L WarnerLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Stephanie L GraffLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Christopher G AzzoliLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Eric T WongLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Liang ChengLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Sendurai A ManiLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Howard P SafranLegorreta Cancer Center at Brown University, Providence, RI 02912, USA.
Casey WilliamsAvera Cancer Institute, Sioux Falls, SD 57105, USA.
Tobias MeissnerAvera Cancer Institute, Sioux Falls, SD 57105, USA.
Benjamin SolomonAvera Cancer Institute, Sioux Falls, SD 57105, USA.
Eitan RubinBen-Gurion University of the Negev, Be'er Sheva, Israel.
Angel PorgadorBen-Gurion University of the Negev, Be'er Sheva, Israel.
Guy BerchemCentre Hospitalier du Luxembourg, Luxembourg.
Pierre SaintignyDepartment of Medical Oncology, Centre Léon Bérard, Lyon, France.
Amir OnnJusidman Cancer Center, Sheba Medical Center, Ramat Gan, Israel.
Jair BarJusidman Cancer Center, Sheba Medical Center, Ramat Gan, Israel.
Raanan BergerJusidman Cancer Center, Sheba Medical Center, Ramat Gan, Israel.
Manon GantenbeinLuxembourg Institute of Health, Luxembourg.
Zhen ChenFudan University Shanghai Cancer Center, Shanghai, China.
Cristiano de Pádua SouzaMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
Rui Manuel Vieira ReisMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil.
Marina SekachevaI.M Sechenov First Medical State University, Moscow, Russian Federation.
Andrés CervantesINCLIVA Instituto de Investigación Sanitaria, Valencia, Spain.
William L DahutAmerican Cancer Society, Atlanta, Georgia, MD 21742, USA.
Christina M AnnunziataAmerican Cancer Society, Atlanta, Georgia, MD 21742, USA.
Kerri GoberAmerican Cancer Society, Atlanta, Georgia, MD 21742, USA.
Khaled M MusallamBurjeel Medical City (BMC), Mohamed Bin Zayed City, Abu Dhabi, UAE.
Humaid O Al-ShamsiBurjeel Medical City (BMC), Mohamed Bin Zayed City, Abu Dhabi, UAE.
Ibrahim Abu-GheidaBurjeel Medical City (BMC), Mohamed Bin Zayed City, Abu Dhabi, UAE.
Ramon SalazarMedical Oncology Deparment. Institut Català d'Oncologia. Oncobell Program (IDIBELL), Universitat de Barcelona (Campus Bellvitge), CIBERONC, Barcelona, Spain.
Sewanti LimayeSir H.N. Reliance Foundation Hospital and Research Centre, Mumbai, India.
Adel T ArefProCan, Children's Medical Research Institute, The University of Sydney, Australia.
Roger R ReddelProCan, Children's Medical Research Institute, The University of Sydney, Australia.
Mohammed Ussama Al HomsiNational Center for Cancer Care and Research Hamad Medical Corporation, Doha, Qatar.
Abdul RoufNational Center for Cancer Care and Research Hamad Medical Corporation, Doha, Qatar.
Said DermimeNational Center for Cancer Care and Research Hamad Medical Corporation, Doha, Qatar.
Jassim Al SuwaidiNational Center for Cancer Care and Research Hamad Medical Corporation, Doha, Qatar.
Catalin VladOncology Institute Ion Chiricuta, Cluj, Romania.
Rares BuigaOncology Institute Ion Chiricuta, Cluj, Romania.
Amal Al OmariKing Hussein Cancer Center, Amman, Jordan.
Hikmat Abdel-RazeqKing Hussein Cancer Center, Amman, Jordan.
Luis F Oñate-OcañaInstituto Nacional de Cancerología (INCan), Mexico City, Mexico.
Finn Cilius NielsenRigshospitalet, Copenhagen, Denmark.
Leah GrahamThe Jackson Laboratory, The Maine Cancer Genomics Initiative, Bar Harbor, ME 04609, USA.
Jens RueterThe Jackson Laboratory, The Maine Cancer Genomics Initiative, Bar Harbor, ME 04609, USA.
Anthony M JoshuaThe Kinghorn Cancer Centre, St Vincent's Hospital, Darlinghurst, Australia.
Eugenia GirdaRutgers Cancer Institute, New Brunswick, NJ 08901, USA.
Steven LibuttiRutgers Cancer Institute, New Brunswick, NJ 08901, USA.
Gregory RiedlingerRutgers Cancer Institute, New Brunswick, NJ 08901, USA.
Mohammed E SalemWake Forest University Health Sciences/Atrium Health (WFUHS), Winston-Salem, NC 27157, USA.
Carol J FarhangfarWake Forest University Health Sciences/Atrium Health (WFUHS), Winston-Salem, NC 27157, USA.
Ruben A MesaWake Forest University Health Sciences/Atrium Health (WFUHS), Winston-Salem, NC 27157, USA.
Bishoy M FaltasWeill Cornell Medical College, NY 10065, USA.
Olivier ElementoWeill Cornell Medical College, NY 10065, USA.
C S PrameshTata Memorial Centre, Affiliated to Homi Bhabha National Institute, Mumbai, India.
Manju SengarTata Memorial Centre, Affiliated to Homi Bhabha National Institute, Mumbai, India.
Satoru AoyamaInstitute of Science Tokyo Hospital, Tokyo, Japan.
Sadakatsu IkedaInstitute of Science Tokyo Hospital, Tokyo, Japan.
Ioana Berindan-NeagoeUniversity of Medicine and Pharmacy Iuliu Hatieganu, Cluj, Romania.
Himabindu GaddipatiVyas Cancer Research (VCR Park), Maharanipeta, Visakhpatnam, Andhra Pradesh, India.
Mandar KulkarniVyas Cancer Research (VCR Park), Maharanipeta, Visakhpatnam, Andhra Pradesh, India.
Elisabeth AuziasCure51, Paris, France.
Maria GerogianniCure51, Paris, France.
Nicolas WolikowCure51, Paris, France.
Simon IstolainenCure51, Paris, France.
Pessie SchlafrigCHAIM Medical Resource Organization, NY 10950, USA.
Naftali Z FrankelCHAIM Medical Resource Organization, NY 10950, USA.
Amanda R FerraroCancer is an A*, LLC, Manalapan Township, NJ 07726, USA.
Jim PalmaTargetCancer Foundation, Cambridge, MA 02139, USA.
Alejandro Piris GimenezVall d'Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.
Alberto Hernando-CalvoVall d'Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.
Enriqueta FelipVall d'Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.
Apostolia M TsimberidouThe University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Roy S HerbstYale School of Medicine, New Haven, CT 06510, USA.
Josep TaberneroVall d'Hebron Hospital Campus and Institute of Oncology (VHIO), Barcelona, Spain.
Richard L SchilskyThe University of Chicago, Chicago, IL 60637, USA.
Jia LiuProCan, Children's Medical Research Institute, The University of Sydney, Australia.
Yves LussierWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
Jacques RaynaudWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
Gerald BatistSegal Cancer Centre, Jewish Hospital, McGill University, Montreal, Quebec, Canada.
Shai MagidiWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.
Razelle KurzrockWorldwide Innovative Network (WIN) Association - WIN Consortium, Chevilly-Larue, France.

Funding

SWOG Network Group Operations Center of the NCTNU10CA180888 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PRIMO N. LARA · 2014 to 2026
$152.1M
Medical College of Wisconsin Lead Academic Participating Site RenewalUG1CA233198 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI William H Bradley, Elizabeth M Gore · 2019 to 2026
$5.0M
NCI NIH HHS U10 CA180888NCI NIH HHS UG1 CA233198
6 · The paper itself

Abstract

The human genome project ushered in a genomic medicine era that was largely unimaginable three decades ago. Discoveries of druggable cancer drivers enabled biomarker-driven gene- and immune-targeted therapy and transformed cancer treatment. Minimizing treatment not expected to benefit, and toxicity-including financial and time-are important goals of modern oncology. The Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine founded by Drs. John Mendelsohn and Thomas Tursz provided a vision for innovation, collaboration and global impact in precision oncology. Through pursuit of transcriptomic signatures, artificial intelligence (AI) algorithms, global precision cancer medicine clinical trials and input from an international Molecular Tumor Board (MTB), WIN has led the way in demonstrating patient benefit from precision-therapeutics through N-of-1 molecularly-driven studies. WIN Next-Generation Precision Oncology (WINGPO) trials are being developed in the neoadjuvant, adjuvant or metastatic settings, incorporate real-world data, digital pathology, and advanced algorithms to guide MTB prioritization of therapy combinations for a diverse global population. WIN has pursued combinations that target multiple drivers/hallmarks of cancer in individual patients. WIN continues to be impactful through collaboration with industry, government, sponsors, funders, academic and community centers, patient advocates, and other stakeholders to tackle challenges including drug access, costs, regulatory barriers, and patient support. WIN's collaborative next generation of precision oncology trials will guide treatment selection for patients with advanced cancers through MTB and AI algorithms based on serial liquid and tissue biopsies and exploratory omics including transcriptomics, proteomics, metabolomics and functional precision medicine. Our vision is to accelerate the future of precision oncology care.

Indexed as

Medical OncologyNeoplasmsPrecision MedicineArtificial IntelligenceBiomarkers, TumorGenomicsHumansBiomarkers, TumorAI algorithmsdigital pathologydrug accessN-of-1 basket trialsprecision oncology

Identifiers

PMID40073368
PMCPMC11907938

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.