Observational studyThe New England journal of medicine2025
Incidence of Scrub Typhus in Rural South India.
Observational study in The New England journal of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04506944 (The Epidemiology Of Scrub Typhus And Rickettsial Infections In A Highly Endemic Rural Setting In South India), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Epidemiology Of Scrub Typhus And Rickettsial Infections In A Highly Endemic Rural Setting In South India: Population-Based Cohort Study
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Sero-Diagnosis of Scrub Typhus Infection in India: A Systematic Review and Meta-Analysis.Tropical medicine & international health : TM & IH · 2026Pooled it
- Etiologies of community-acquired febrile illness identified by TaqMan Array Card qPCR on blood samples: a systematic review and meta-analysis.Journal of clinical microbiology · 2026Pooled it
- Movement Disorders in Scrub Typhus: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Pooled it
- Global epidemiology of myocarditis: disparities in age, sex and geography.Nature reviews. Cardiology · 2026Review
- Review
- Clinical features and risk factors for severe pediatric scrub typhus in Liangshan Prefecture, China: A retrospective cohort study.BMC pediatrics · 2026Article
- First molecular evidence of Rickettsia spp. in Triatoma rubrofasciata: implications for vector ecology and zoonotic transmission.Parasites & vectors · 2026Article
- Cost of illness of scrub typhus in South India - a population-based, mixed-methods study.PLoS neglected tropical diseases · 2026Article
- Leptotrombidium imphalum Chiggers as Vector for Scrub Typhus in Human Settlements, India, 2022-2023.Emerging infectious diseases · 2026Article
- Tissue distribution of Orientia tsutsugamushi in rodents: a molecular and immune diagnostic approach.Molecular biology reports · 2026Article
- Scrub Typhus in Pregnancy: A Retrospective Observational Study From Primary Hospital of Southwest China.Journal of tropical medicine · 2026Article
- A case of acute pulmonary edema in scrub typhus: a rare complication with normal cardiac and renal function.BMC infectious diseases · 2025Article
- Risk factors for scrub typhus infection in South India: population-based cohort study.Epidemiology and infection · 2025Observational
- Comparative Analysis of Scrub Typhus Rapid Kits and Their Relevance in Screening and Diagnosis.Cureus · 2025Article
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11 authors.
Funding
Abstract
backgroundHospital studies suggest that scrub typhus is a leading cause of severe undifferentiated fever in regions across Asia where the disease is endemic, but the population-based incidence of infection and illness has been little studied.
methodsWe conducted a population-based cohort study to assess epidemiologic and clinical characteristics of scrub typhus in 37 villages in Tamil Nadu, India, where the disease is highly endemic. Study participants were visited every 6 to 8 weeks over a period of 2 years; a venous blood sample was obtained from those who had had fever since the last visit. A subcohort of participants underwent blood sampling to estimate the incidence of serologically confirmed
resultsWe systematically assessed 32,279 participants from 7619 households for acute febrile illness. During 54,588 person-years of follow-up, we observed 6175 episodes of fever. A blood sample was obtained in 4474 episodes (72.5%), of which 328 (7.3%) met the clinical case definition of scrub typhus (detection of IgM against
conclusionsWe describe the burden of scrub typhus, including the incidence of asymptomatic infection, in a region of Asia where the disease is endemic. (Funded by the U.K. Medical Research Council; ClinicalTrials.gov number, NCT04506944.).
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