ArticleRheumatology (Oxford, England)2025
Using a smartphone app to monitor Raynaud's attacks and quantify skin colour changes-towards objective outcome measures for Raynaud's.
Article in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cold Hands, Warm Heart: Quality of life, wellbeing, and mental health in Raynaud's disease - An international survey study.Journal of health psychology · 2026Article
- Artificial intelligence-based Raynaud's quantification index (ARTIX): an objective mobile-based tool for patient-centered assessment of Raynaud's phenomenon.Arthritis research & therapy · 2025Article
- Technetium-99m hand perfusion scintigraphy (Raynaud's scan) as a method of verification in hand arm vibration syndrome: a review.Annals of occupational and environmental medicine · 2022Review
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Authors and funding
6 authors.
Funding
Abstract
objectivesOur overall aim was to develop a smartphone app to collect photographic images of Raynaud's phenomenon (RP) attacks alongside patient reported outcome measures (PROMs). Specific objectives included assessing the feasibility of patients documenting RP attacks using mobile phones, developing image analysis methods to document colour change, and comparing photographic parameters with 'non-imaging' app and paper diary parameters.
methodsIn study 1, 36 patients with systemic sclerosis (SSc)-related RP photographed RP attacks over 15 days as well as completing an RP paper diary. In study 2, 40 patients with either SSc-related or primary RP used a smartphone app to collect, over 15 days, photographic images and data including frequency and severity of attacks. In both studies, mean colour change during each attack (indicating severity) was quantified by the Bhattacharyya distance.
resultsIn study 1, 24/36 (67%) patients completed the study of whom 22 photographed at least one RP attack (median number of attacks 12.5, range 1-53); 18/24 (75%) patients preferred phone to paper diary documentation. 'Photographic' and 'paper diary' frequency (but not severity) of attacks correlated strongly, with a correlation coefficient of 0.71 (95% CI: 0.41, 0.87); P = 0.002. In study 2, 36/40 (90%) completed the study, providing 1747 usable images from 456 RP attacks. ANOVA demonstrated that RP colour change was significantly different with different values of RP attack severity (P <0.001).
conclusionCollecting photographs of RP attacks and PROMS via a smartphone app was feasible and preferred by patients to data collection via paper diary, providing proof-of-concept for validation studies of app-based outcome measures for RP.
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