Evidence map›Paper›PMID 40073145›Full record

ArticleScience advances2025

Phagocytosis-driven neurodegeneration through opposing roles of an ABC transporter in neurons and phagocytes.

Xinchen Chen, Bei Wang, Ankita Sarkar, Zixian Huang, Nicolas Vergara Ruiz, Ann T Yeung, Rachael Chen, Chun Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Clonal Analysis inBio-protocol · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xinchen ChenWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-2606-6502
Bei WangWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3002-3302
Ankita SarkarWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-0970-2776
Zixian HuangWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0008-0970-8781
Nicolas Vergara RuizWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-6591-5234
Ann T YeungWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0009-0007-9824-6816
Rachael ChenWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
Chun HanWeill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-7319-8095

Funding

MAGIC tools for genome-wide mosaic analysis with existing Drosophila resources (Equipment Supplement 2023)R24OD031953 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2022 to 2025
$3.1M
Mechanisms of the recognition of degenerating dendritesR01NS099125 · NINDS · CORNELL UNIVERSITY · PI HAN, CHUN · 2016 to 2020
$2.1M
A light-inducible protein trapping system for studying cellular dynamics in DrosophilaR21OD023824 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2017 to 2018
$414k
NIH HHS R21 OD023824NIH HHS R24 OD031953NINDS NIH HHS R01 NS099125
6 · The paper itself

Abstract

Lipid homeostasis is critical to neuronal survival. ATP-binding cassette A (ABCA) proteins are lipid transporters associated with neurodegenerative diseases. How ABCA transporters regulate lipid homeostasis in neurodegeneration is an outstanding question. Here we report that the

Indexed as

ATP-Binding Cassette TransportersDrosophila ProteinsNeurodegenerative DiseasesNeuronsPhagocytesPhagocytosisAnimalsDrosophila melanogasterHumansATP-Binding Cassette TransportersDrosophila Proteins

Identifiers

PMID40073145
PMCPMC11900885

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.