Evidence map›Paper›PMID 40073131›Full record

ArticleScience advances2025

Counterions influence the isothermal self-assembly of DNA nanostructures.

Arlin Rodriguez, Bharath Raj Madhanagopal, Kahini Sarkar, Zohreh Nowzari, Johnsi Mathivanan, Hannah Talbot, Akul Patel, Vinod Morya, Ken Halvorsen, Sweta Vangaveti and 2 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Light-responsive DNA nanostructures.Nature reviews. Chemistry · 2026
    Review
  4. DNA Nanostructures for siRNA Delivery.Bioconjugate chemistry · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. DNA nanocarriers for nucleic acid drug delivery.Expert opinion on drug delivery · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Isothermal assembly of DNA nanostructures.Chemical communications (Cambridge, England) · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Arlin RodriguezThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0009-0003-3288-1121
Bharath Raj MadhanagopalThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0000-0003-1043-8754
Kahini SarkarThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Zohreh NowzariThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0009-0001-9574-0241
Johnsi MathivananThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Hannah TalbotThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0009-0002-5229-2220
Akul PatelThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0009-0005-8566-0327
Vinod MoryaThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0000-0002-1539-4108
Ken HalvorsenThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0000-0002-2578-1339
Sweta VangavetiThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
J Andrew BerglundThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0000-0002-5198-2724
Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.ORCID 0000-0001-6757-5464

Funding

Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnologyR35GM124720 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Ken A Halvorsen · 2017 to 2026
$4.6M
Programmable DNA Nanostructures as Biomedical and Structural ScaffoldsR35GM150672 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Arun Richard Chandrasekaran · 2023 to 2026
$1.7M
DNA Nanostructures as siRNA Delivery Vehicles for Alzheimer's TherapyR03AG076599 · NIA · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CHANDRASEKARAN, ARUN RICHARD · 2022 to 2023
$425k
NIA NIH HHS R03 AG076599NIGMS NIH HHS R35 GM124720NIGMS NIH HHS R35 GM150672
6 · The paper itself

Abstract

DNA nanostructures are typically assembled by thermal annealing in buffers containing magnesium. We demonstrate the assembly of DNA nanostructures at constant temperatures ranging from 4° to 50°C in solutions containing different counterions. The choice of counterions and the assembly temperature influence the isothermal assembly of several DNA motifs and designed three-dimensional DNA crystals. Molecular dynamics simulations show more fluctuations of the DNA structure in select monovalent ions (Na

Indexed as

DNANanostructuresAnimalsCalciumIonsMagnesiumMiceMolecular Dynamics SimulationNickelNucleic Acid ConformationTemperatureCalciumDNAIonsMagnesiumNickel

Identifiers

PMID40073131
PMCPMC13109936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.