ArticleScience advances2025
Active microgel particle swarms for intrabronchial targeted delivery.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
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Who cites it
13 citing papers in PubMed.
- Three-dimensional reconfigurable magnetic microswarms with boundary-transcending capabilities.Science advances · 2026Article
- Structural Evolution of Biomedical Microrobots: From Rigid to Soft to Rigid-Soft Integrated Systems.Gels (Basel, Switzerland) · 2026Review
- Task-Oriented Biomedical Microrobots: Access, Working Environment, Actuation, Body Design, Detection and Control.Micromachines · 2026Review
- A ciliated intravascular soft millirobot for multimodal in-flow collective manipulation.Science advances · 2026Article
- Magnetic-Driven Wheel-Like Microswarms Based on Mechanical Grinding for Cancer Treatment.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Multi-Legged Magnetic Soft Robot for On-Demand Targeted Delivery in Pulmonary Environments.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Recent Advances in Responsive Microgels for Biomedical Application.Bioengineering (Basel, Switzerland) · 2026Review
- Autonomous Microrobots for Spatiotemporally Active Therapeutic Delivery and Controlled Release.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Inhaled Targeted Nano-Drug Delivery Systems for COPD: Precision Solutions to Clinical Barriers.International journal of nanomedicine · 2026Review
- Hybrid-Driven Bacillus Calmette-Guérin Carrier for Targeted Immuno-Chemo Combo Therapy in Bladder Cancer.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Hyaluronic acid-based microgels loaded with fluticasone furoate for bleomycin-induced acute lung injury treatment.Materials today. Bio · 2025Article
- Article
- Microrobotic Swarms for Cancer Therapy.Research (Washington, D.C.) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrabronchial delivery of therapeutic agents is critical to the treatment of respiratory diseases. Targeted delivery is demanded because of the off-target accumulation of drugs in normal lung tissues caused by inhalation and the limited motion dexterity of clinical bronchoscopes in tortuous bronchial trees. Herein, we developed microrobotic swarms consisting of magnetic hydrogel microparticles to achieve intrabronchial targeted delivery. Under programmed magnetic fields, the microgel particle swarms performed controllable locomotion and adaptative structure reconfiguration in tortuous and air-filled environments. The swarms were further integrated with imaging contrast agents for precise tracking under x-ray fluoroscopy and computed tomography imaging. Magnetic navigation of the swarms in an ex vivo lung phantom and in vivo delivery into deep branches of the bronchial trees were achieved. The on-demand reconfiguration of swarms for avoiding the microgel particles from entering nontarget bronchi and the precise delivery into tilted bronchi through climbing motion were validated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.