ArticleScience advances2025
Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.
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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Mechanisms of neuropeptide-mediated immune sensing in the modulation of antitumor immunity.Journal for immunotherapy of cancer · 2026Review
- Neural regulation in lung cancer: from mechanisms to new therapeutic perspectives.Clinical and experimental medicine · 2026Review
- Neuropeptide Y in cancer metastasis and chemoresistance.Neuropeptides · 2026Review
- Neuropeptide Y as a Neuro-Immune Checkpoint in Cancer.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Review
- OTUD4 regulates pancreatic cancer progression via Hippo/YAP axis.Neoplasia (New York, N.Y.) · 2026Article
- Mechanistic insights into hepatic metastasis of pancreatic cancer: molecular perspectives.Translational gastroenterology and hepatology · 2026Review
- The liver talks back: NPY orchestrates attraction of cancer cells and CHK2-dependent clonogenicity in the metastatic niche.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies.Military Medical Research · 2025Review
Corrections and comments
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Authors and funding
66 authors.
Cecilia R ChambersCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-4979-9349
Supitchaya WatakulCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0009-0003-2887-5466
Peter SchofieldCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0009-0008-1541-2549
Anna E HowellCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-6207-182X
Jessie ZhuCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Alice M H TranCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Nadia KuepperCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Daniel A ReedCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-3736-7725
Kendelle J MurphyCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-3234-3812
Lily M ChannonCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-4456-4233
Brooke A PereiraCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0003-3513-1214
Victoria M TymaCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0009-0005-7959-4407
Victoria LeeCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-0701-8321
Michael TrpceskiCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0001-5430-2205
Jake HenryCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0003-0435-3308
Pauline MelenecCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0001-6486-2003
Lea AbdulkhalekCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Max NobisCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-1861-1390
Xanthe L MetcalfCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0001-9599-9280
Shona RitchieCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0001-9234-0632
Antonia CadellCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-3560-4125
Janett StoehrCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-4198-3520
Astrid MagenauCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Diego Chacon-FajardoCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0003-3729-1385
Jessica L ChittyCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0003-1776-1618
Savannah O'ConnellImmune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0009-0005-4006-8514
Anaiis ZaratzianCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Michael TayaoCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0001-5224-0784
Andrew Da SilvaCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Ruth J LyonsCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Leonard D GoldsteinSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.ORCID 0000-0003-4645-553X
Ashleigh DaleSydney Mass Spectrometry, University of Sydney, Sydney, New South Wales, Australia.
Alexander RookyardSydney Mass Spectrometry, University of Sydney, Sydney, New South Wales, Australia.
Angela ConnollySydney Mass Spectrometry, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-2959-4001
Ben CrossettSydney Mass Spectrometry, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-5366-4554
Yen T H TranAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia.ORCID 0000-0003-1414-2328
Peter KaltzisAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia.ORCID 0000-0003-2790-6606
Claire VenninCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Marija DinevskaCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-0532-1458
Australian Pancreatic Cancer Genome Initiative (APGI)
Australian Pancreatic Cancer Matrix Atlas (APMA)
David R CroucherSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.ORCID 0000-0003-4965-8674
Jaswinder SamraRoyal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
Anubhav MittalRoyal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
Robert J WeatherittImmune Biotherapies Program, Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0003-3716-1783
Andrew PhilpCentre for Healthy Ageing, Centenary Institute, Sydney, New South Wales, Australia.
Gonzalo Del Monte-NietoAustralian Regenerative Medicine Institute, Monash University, Clayton, Victoria 3800, Australia.ORCID 0000-0003-3830-2226
Lei ZhangSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.
Ronaldo F EnriquezCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.
Thomas R CoxCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0001-9294-1745
Yan-Chuan C ShiCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-8368-6735
Mark PineseSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.ORCID 0000-0001-5078-6687
Nicola WaddellQIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.ORCID 0000-0002-3950-2476
Hao-Wen SimCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-2530-0523
Tatyana ChtanovaCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0003-3419-4483
Yingxiao WangDepartment of Bioengineering & Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0003-0265-326X
Anthony M JoshuaSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.ORCID 0000-0001-5159-4580
Lorraine ChantrillDepartment of Medical Oncology and Illawarra Shoalhaven Local Health District, Wollongong, New South Wales, Australia.ORCID 0000-0002-5790-0208
Thomas R Jeffry EvansCancer Research UK Scotland Institute, Glasgow, UK.
Anthony J GillCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-9447-1967
Jennifer P MortonCancer Research UK Scotland Institute, Glasgow, UK.ORCID 0000-0001-5766-9141
Marina PajicSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.ORCID 0000-0002-3871-3829
Daniel ChristCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-7313-3977
Herbert HerzogSchool of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, New South Wales, Australia.ORCID 0000-0002-1713-1029
Paul TimpsonCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-5514-7080
David HerrmannCancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, New South Wales, Australia.ORCID 0000-0002-9514-7501
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorigenesis in a range of cancer types, but its role in PC has yet to be explored. We show that expression of NPY and
Indexed as
MutationNeuropeptide YPancreatic NeoplasmsReceptors, Neuropeptide YSignal TransductionTumor Suppressor Protein p53AnimalsArginineCell Line, TumorCell MovementDisease Models, AnimalGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMiceMice, KnockoutArginineBIBO 3304Neuropeptide Yneuropeptide Y-Y1 receptorNpy1r protein, mouseReceptors, Neuropeptide YTumor Suppressor Protein p53
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.