Evidence map›Paper›PMID 40073078›Full record

ArticleeLife2025

Proteostasis modulates gene dosage evolution in antibiotic-resistant bacteria.

Chinmaya Jena, Saillesh Chinnaraj, Soham Deolankar, Nishad Matange

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chinmaya JenaDepartment of Biology, Indian Institute of Science Education and Research, Pune, India.ORCID https://orcid.org/0000-0002-4401-3570
Saillesh ChinnarajDepartment of Biology, Indian Institute of Science Education and Research, Pune, India.
Soham DeolankarDepartment of Biology, Indian Institute of Science Education and Research, Pune, India.
Nishad MatangeDepartment of Biology, Indian Institute of Science Education and Research, Pune, India.ORCID https://orcid.org/0000-0002-2947-3931

Funding

Wellcome TrustWellcome Trust/DBT India Alliance IA/I/20/2/505181
6 · The paper itself

Abstract

Evolution of gene expression frequently drives antibiotic resistance in bacteria. We had previously (Patel and Matange,

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialEscherichia coliEvolution, MolecularGene DosageProteostasisEscherichia coli ProteinsGene DuplicationGene Expression Regulation, BacterialTetrahydrofolate DehydrogenaseTrimethoprimAnti-Bacterial AgentsEscherichia coli ProteinsTetrahydrofolate DehydrogenaseTrimethoprimantimicrobial resistancedihydrofolate reductaseE. coligene duplicationgeneticsgenomicsinfectious diseasemicrobiologyproteostasistrimethoprim

Identifiers

PMID40073078
PMCPMC11903035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.