Evidence map›Paper›PMID 40073060›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Dual-filament regulation of relaxation in mammalian fast skeletal muscle.

Cameron Hill, Michaeljohn Kalakoutis, Alice Arcidiacono, Flair Paradine Cullup, Yanhong Wang, Atsuki Fukutani, Theyencheri Narayanan, Elisabetta Brunello, Luca Fusi, Malcolm Irving

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Muscle Diffraction at the Life Science X-ray Scattering Beamline.bioRxiv : the preprint server for biology · 2026
    Article
  7. Popping the hood of muscle motors using time-resolved, small-angle X-ray diffraction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Dual-filament regulation of relaxation in mammalian fast skeletal muscle.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Cameron HillRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0002-0815-5109
Michaeljohn KalakoutisRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.
Alice ArcidiaconoRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.
Flair Paradine CullupRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0009-0000-7285-0117
Yanhong WangRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0002-4257-3195
Atsuki FukutaniRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0002-8572-7940
Theyencheri NarayananEuropean Synchrotron Radiation Facility, Grenoble 38043, France.ORCID 0000-0003-1957-1041
Elisabetta BrunelloRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0003-3167-4828
Luca FusiRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0003-3992-0114
Malcolm IrvingRandall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Research Excellence, New Hunt's House, Guy's Campus, King's College London, London SE1 1UL, United Kingdom.ORCID 0000-0001-6419-3583

Funding

British Heart Foundation (BHF) FS/17/3/32604British Heart Foundation (BHF) RE/18/2/34213European Synchrotron Radiation Facility (ESRF) LS-3080 & LS-3206Royal Society (The Royal Society) 210464/Z/18/ZUKRI | Medical Research Council (MRC) MR/R01700X/1Wellcome TrustWellcome Trust (WT) 210464/Z/18/ZWellcome Trust (WT) 215482/Z/19/Z
6 · The paper itself

Abstract

Muscle contraction is driven by myosin motors from the thick filaments pulling on the actin-containing thin filaments of the sarcomere, and it is regulated by structural changes in both filaments. Thin filaments are activated by an increase in intracellular calcium concentration [Ca

Indexed as

Actin CytoskeletonMuscle RelaxationMuscle, SkeletalActinsAnimalsCalciumMiceMuscle ContractionMyosinsSarcomeresX-Ray DiffractionActinsCalciumMyosinsactinmammalian skeletal musclemyosinsmall-angle X-ray diffractiontropomyosin

Identifiers

PMID40073060
PMCPMC11929500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.