Observational studyPLoS neglected tropical diseases2025
Assessing the global dengue burden: Incidence, mortality, and disability trends over three decades.
Observational study in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic mapping review of therapeutic clinical trials in dengue.PLoS neglected tropical diseases · 2026Pooled it
- Diagnostic accuracy of recombinase polymerase amplification-based assays for mosquito-borne virus detection in clinical samples: a systematic review and meta-analysis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Associations of serum 25-hydroxyvitamin D and vitamin D receptor polymorphisms with dengue severity in hospitalized Vietnamese children.IJID regions · 2026Article
- Unresolved questions in pediatric dengue: from disease mechanisms to prevention.Current opinion in infectious diseases · 2026Review
- Parameters Affecting Dengue Virus Replication in Vero Cells.Vaccine: X · 2026Article
- Vector competence acrossJournal of virology · 2026Review
- A spatiotemporal U-Net++ deep learning framework for dengue risk mapping in Colombia.Scientific reports · 2026Article
- Assessing the burden of diabetes mellitus in dengue patients: A systematic review and meta-analysis.New microbes and new infections · 2026Article
- From buckets to backyards: a typology of community-based copepod interventions for Aedes vector control-a narrative review.Parasites & vectors · 2026Review
- Global, Regional, and National Burden of Malaria and Dengue from 1992 to 2021, with Projections to 2036: An Age-Period-Cohort Analysis.Tropical medicine and infectious disease · 2026Article
- Acute-Phase Dengue Antibody Profiles in Pediatric Patients: Influence on Viremia and Disease Manifestations.Viruses · 2026Article
- Outcomes of dengue infection in adults with underlying haematological diseases in Brazil during 2024 and 2025.British journal of haematology · 2026Article
- Serotype skewing and immune imprinting shape response to the tetravalent dengue virus Qdenga vaccine.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Article
- A 13-year cohort study using clinical machine learning to differentiate bacterial and viral infections in young infants in a dengue hyperendemic region.Journal of tropical pediatrics · 2026Article
- Computational identification of conserved dengue virus envelope protein epitopes for vaccine design and immunodiagnostic platform.Scientific reports · 2026Article
- The Second Silent Pandemic: Why Arboviruses Demand an Orchestrated Global Health Response.Pathogens (Basel, Switzerland) · 2026Review
- Improved and customized dengue serodiagnostics through combined NS1/IgM testing and novel dual-cut-off IgG ELISA.PLoS neglected tropical diseases · 2026Article
- Pharmaceutical design of mRNA vaccines for endemic infectious diseases: integrating antigen discovery with platform engineering.Clinical and experimental vaccine research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundDengue, the fastest-spreading vector-borne disease (VBD), significantly burdens global health systems. This study analyzed the trends in the global burden of dengue from 1990 to 2021, utilizing data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021). METHODOLOGY/PRINCIPAL
findingsWe retrieved data from GBD 2021 regarding dengue, including the number of incidences and age-standardized incidence rate (ASIR), the number of deaths and age-standardized death rate (ASDR), disability-adjusted life-years (DALYs) and age-standardized DALYs. The estimated annual percentage change (EAPC) of ASIR, ASDR, and standardized DALYs rate was calculated to quantify trends over time. In addition, the correlations between dengue burden and sea level rise, as well as the Socio-Demographic Index (SDI), were evaluated. In this study, it was observed that from 1990 to 2021, the global incidence of dengue escalated from 26.45 million to 58.96 million cases, accompanied by an increase in related deaths from 14,315 to 29,075, and DALYs rising from 1.25 million to 2.08 million years. These data collectively indicate that the disease burden approximately doubled, with South Asia, Southeast Asia, and tropical Latin America being the most severely affected regions. The disease burden remained substantial in middle and low-middle-SDI regions, whereas high-middle and high SDI regions experienced pronounced growth rates in ASIR, ASDR, and age-standardized DALYs rate. Adolescents and the elderly showed higher incidence, yet children under 5 had the highest DALYs. Correlation analyses revealed an inverted U-shaped relationship between the SDI and both the ASDR and age-standardized DALYs rate, and changes in sea level height strongly correlated with the overall dengue burden. CONCLUSIONS/SIGNIFICANCE: The global dengue burden has surged due to climate change, vector transmission, and population mobility. Increased focus and tailored control strategies are essential, particularly in South Asia, Southeast Asia, and Latin America.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.