Comparison of health-related quality of life trajectories in older breast cancer survivors and noncancerous controls over 10 years: A SEER-MHOS analysis.

Maria Eduarda de Azevedo Daruge, Jianbin Zhu, Jaeyoung Park, Robert B Hines, Eunkyung Lee

Abstract readComparative Study

In one paragraph

Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Maria Eduarda de Azevedo DarugeDepartment of Health Sciences, University of Central Florida College of Health Professions and Sciences, 4364 Scorpius Street, Orlando, FL, USA.

Jianbin ZhuCenter for Academic Research Excellence, Research Institute, Advent Health, Orlando, FL, USA.

Jaeyoung ParkSchool of Global Health Management and Informatics, University of Central Florida College of Community Innovation and Education, Orlando, FL, USA.

Robert B HinesDepartment of Population Health Sciences, University of Central Florida College of Medicine, Orlando, FL, USA.

Eunkyung LeeDepartment of Health Sciences, University of Central Florida College of Health Professions and Sciences, 4364 Scorpius Street, Orlando, FL, USA. eunkyung.lee@ucf.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study analyzed the long-term effects of cancer on the health-related quality of life (HRQOL) of older breast cancer survivors for 10 years, including a control group to distinguish between the impacts of cancer treatment and aging.

methodsThe SEER-MHOS data resource was used in the analysis. Cases were 674 older women diagnosed with breast cancer in 1998-2015 at age 65 and older and participated in Medicare Health Outcomes Survey within 24 months before their cancer diagnosis and at least once within 10 years of post-diagnosis. Propensity score-matched controls (n = 674) were randomly selected from noncancer cohorts. Participants reported their HRQOL using SF-36/VR-12. Repeated measures two-way analysis of variance was used to assess the effects of time, group, and the interaction between time and group on long-term HRQOL trajectory up to 10 years of follow-up.

resultsAt baseline, cases fared worse than controls in all HRQOL domains. Over time, physical component summary, physical functioning, general health, role limitation due to physical health, bodily pain, social functioning, and vitality worsened (P

conclusionsBoth cases and controls experienced physical HRQOL deterioration, but relatively stable mental HRQOL over 10 years. IMPLICATIONS FOR CANCER SURVIVORS: Early interventions focusing on physical health are warranted to maintain HRQOL among older women diagnosed with breast cancer.

Indexed as

Breast NeoplasmsCancer SurvivorsQuality of LifeAgedAged, 80 and overCase-Control StudiesFemaleHumansSEER ProgramUnited StatesBreast cancerOlder cancer survivorsPropensity score matchingQuality of lifeSEER-MHOSTrajectory

Identifiers

PMID40072835

DOI10.1007/s11764-025-01745-0

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