Evidence map›Paper›PMID 40072810›Full record

ArticleInternational ophthalmology2025

Safety of intravitreal injections with the mobile laminar airflow device Operio after more than 10.000 injections.

Tito Fiore, Nicola De Santi, Eduardo Bianchi, Alessio Cerquaglia, Marco Lupidi, Gianluigi Tosi, Carlo Cagini

Abstract read
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In one paragraph

Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tito FioreDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.ORCID https://orcid.org/0000-0003-2410-9775
Nicola De SantiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy. nicola.desanti@hotmail.it.ORCID https://orcid.org/0009-0008-5047-4745
Eduardo BianchiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.ORCID https://orcid.org/0009-0005-3423-1071
Alessio CerquagliaDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.ORCID https://orcid.org/0000-0003-2765-0639
Marco LupidiEye Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.ORCID https://orcid.org/0000-0002-6817-2488
Gianluigi TosiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.
Carlo CaginiDepartment of Medicine Surgical, Section of Ophthalmology, University of Perugia, S. Maria Della Misericordia Hospital, 06156, Perugia, Italy.ORCID https://orcid.org/0000-0002-3812-9219

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the occurrence of complications following intravitreal injections (IVIs) performed in an outpatient clean room (OCR) equipped with the mobile laminar airflow device (LAF) Operio.

methodsThis retrospective study analyzed the data of 10,016 IVIs performed in an OCR from April 2023 to November 2024. All information of each patient was registered, such as diagnosis, drug injected and any occurring complication or adverse events such as endophthalmitis, intraocular inflammation, rhegmatogenous retinal detachment (RRD), vitreous hemorrhages and elevated intraocular pressure.

resultsFrom April 2023 to November 2024, 10,016 IVIs were performed in 1700 eyes of 1460 patients with the average age of 76.10 ± 12.37 years. The most representative diagnosis were Age-related Macular Degeneration (AMD) (47.60%), Retinal Vein Occlusion (RVO) (18.90%) and Diabetic Macular Edema (DME) (8.42%). Ten (4.24%) cases of ocular hypertensions were reported after dexamethasone implant whereas no cases of endophthalmitis or RRD were registered.

conclusionsThe OCR equipped with Operio was easy to set up, safe regarding all IVI-related complications, first and foremost endophthalmitis, helpful in improving the management of IVIS, and allowed us to decongest the operating room for more complex surgeries.

Indexed as

Angiogenesis InhibitorsIntravitreal InjectionsRetinal DiseasesAgedAged, 80 and overEndophthalmitisFemaleGlucocorticoidsHumansMaleMiddle AgedRetrospective StudiesVisual AcuityAngiogenesis InhibitorsGlucocorticoidsAirflow deviceEndophthalmitisIntraocular pressureIntravitreal injections

Identifiers

PMID40072810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.