ReviewJournal of ophthalmic inflammation and infection2025
Do people with diabetes have a higher risk of developing postoperative endophthalmitis after cataract surgery? A systematic review and meta-analysis.
Review in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is Botulinum toxin A effective in treating dry eye disease? A systematic review and meta-analysis.Eye (London, England) · 2025Pooled it
- Cataract surgery without a phacoemulsification device during a humanitarian mission in benin: outcomes of manual small-incision cataract surgery and extracapsular cataract extraction.BMC ophthalmology · 2026Article
- Impact of uncomplicated cataract surgery on central retinal thickness changes in diabetic patients: A short-term analysis.The Journal of international medical research · 2026Article
- Posterior migration of an Ahmed glaucoma valve: A case report of a rare postoperative complication.American journal of ophthalmology case reports · 2026Article
- Intracameral antibiotic prophylaxis and surgical expertise: key determinants in endophthalmitis after cataract surgery.International journal of retina and vitreous · 2026Article
- Comparative outcomes of phaco-trabeculectomy versus phaco-tube implantation: a 6-year review.International ophthalmology · 2026Article
- Review
- Expression and clinical significance of IGF-1 and PDGF in aqueous humor and serum of diabetic patients with visually significant cataract.Cytotechnology · 2025Article
- Immunometabolic crossroads: infections as bidirectional modulators in diabetes and metabolic syndromes.Frontiers in endocrinology · 2025Review
- Intraocular Pressure after Uneventful Phacoemulsification in Diabetic and Nondiabetic Patients: A Prospective Observational Study.Journal of current glaucoma practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePostoperative endophthalmitis (POE) is a rare but severe complication of cataract surgery. While diabetes mellitus may increase the risk of POE, the relationship remains unclear.
methodsA systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Scopus, Medline, Embase, and Google Scholar were searched for relevant studies up to September 10, 2024. The study included both randomized controlled trials and observational studies that evaluated POE outcomes in cataract surgery patients, comparing people with and without diabetes. Random-effects models were used to calculate pooled odds ratios (OR) with 95% confidence intervals (CI).
resultsNine studies were included in the systematic review, with seven analyzed in the meta-analysis. The review on POE in people with diabetes undergoing cataract surgery revealed a higher incidence in this group, with a pooled odds ratio (OR) of 1.174 (95% CI: 1.109 to 1.242; p = 0.000) and an incidence rate of 0.261%, compared to 0.242% in people without diabetes. Males with diabetes had a 1.634 times higher risk of POE (p = 0.048), while diabetes and hypertension together increased risk by 3.961 times (p < 0.001). Posterior capsule rupture (PCR) was associated with a significantly higher risk of developing POE, which was also more common in people with diabetes, with an OR of 3.434 (95% CI: 1.789 to 6.591; p = 0.0001). The use of postoperative intracameral and topical antibiotics significantly reduced the risk of POE in both people with and without diabetes (OR: 0.231; p = 0.00).
conclusionsThis meta-analysis shows that people with diabetes undergoing cataract surgery have a significantly higher risk of POE and PCR compared to those without diabetes, with odds ratios of 1.174 and 3.434, respectively. The administration of intracameral and topical antibiotics significantly reduces the risk of POE in both groups. Our study highlights the importance of maintaining well-controlled blood sugar and blood pressure before surgery. Additionally, extra caution should be taken during surgery to prevent PCR, and appropriate antibiotic use should be considered to minimize the risk of POE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.