Evidence map›Paper›PMID 40072687›Full record

ReviewCancer metastasis reviews2025

The functions and modifications of tRNA-derived small RNAs in cancer biology.

Abdulaziz Ahmed A Saad, Kun Zhang, Qianqian Deng, Jiawang Zhou, Lichen Ge, Hongsheng Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cancer metastasis reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Abdulaziz Ahmed A Saad *Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, The State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Kun Zhang *The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Nanbu People'S Hospital; Affiliated Cancer Hospital of Chengdu Medical College, School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, 610500, China.
Qianqian DengGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, The State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Jiawang ZhouGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, The State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China.
Lichen GeDepartment of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China. lichenge@hotmail.com.
Hongsheng WangGuangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, The State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510006, China. whongsh@mail.sysu.edu.cn.

Funding

China Postdoctoral Science Foundation (No. 2024M753801)Clinical Science Research Foundation of Chengdu Medical College (Grant Nos. 2022LHTD-02, 23LHNBZZD07, 24LHBBYY1-08, 24LHBBYY1-09, 24LHFYSZ1-27)CMC Excellent-talent Program (Grant No. 2024kjTzn03)Guangdong Basic and Applied Basic Research Foundation (No. 2023B1515040006 and 2021A1515220048)Guangdong Provincial Key Laboratory of Construction Foundation (2023B1212060022)Guangzhou Science and Technology Program (No. 2024A04J6480)Key-Area Research and Development Program of Guangdong Province (No. 2023B1111020007)National Natural Science Foundation of China (Nos. 82472761, 82173833, 82272658, and 82403178)Natural Science Foundation of Chengdu Medical College (Grant No. 23L009)Organized Research Projects of Chengdu Medical College (Grant No. CYYZZ24-01)Postdoctoral Fellowship Program (Grade C) of China Postdoctoral Science Foundation (No. GZC20233241)Shenzhen Bay Scholars Program, the National Key Research and Development Program of China (No. 2022YFC2601800)
6 · The paper itself

Abstract

Recent progress in noncoding RNA research has highlighted transfer RNA-derived small RNAs (tsRNAs) as key regulators of gene expression, linking them to numerous cellular functions. tsRNAs, which are produced by ribonucleases such as angiogenin and Dicer, are classified based on their size and cleavage positions. They play diverse regulatory roles at the transcriptional, post-transcriptional, and translational levels. Furthermore, tRNAs undergo various modifications that influence their biogenesis, stability, functionality, biochemical characteristics, and protein-binding affinity. tsRNAs, with their aberrant expression patterns and modifications, act as both oncogenes and tumor suppressors. This review explores the biogenetic pathways of tsRNAs and their complex roles in gene regulation. We then focus on the importance of RNA modifications in tsRNAs, evaluating their impact on the biogenesis and biological functions on tsRNAs. Furthermore, we summarize recent data indicating that tsRNAs exhibit varied expression profiles across different cancer types, highlighting their potential as innovative biomarkers and therapeutic targets. This discussion integrates both existing and new knowledge about tsRNAs, emphasizing their importance in cancer biology and clinical advancement.

Indexed as

NeoplasmsRNA, Small UntranslatedRNA, TransferAnimalsGene Expression Regulation, NeoplasticHumansRNA Processing, Post-TranscriptionalRNA, Small UntranslatedRNA, TransferBiomarkerCancerRNA modificationsTherapy targettRNA-derived fragments

Identifiers

PMID40072687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.